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Citation
Li, Q., Hariharan, I.K., Chen, F., Huang, Y., Fischer, J.A. (1997). Genetic interactions with rap1 and ras1 reveal a second function for the fat facets deubiquitinating enzyme in Drosophila eye development.  Proc. Natl. Acad. Sci. U.S.A. 94(23): 12515--12520.
FlyBase ID
FBrf0099363
Publication Type
Research paper
Abstract
The Drosophila fat facets gene encodes a deubiquitinating enzyme that regulates a cell communication pathway essential very early in eye development, prior to facet assembly, to limit the number of photoreceptor cells in each facet of the compound eye to eight. The Fat facets protein facilitates the production of a signal in cells outside the developing facets that inhibits neural development of particular facet precursor cells. Novel gain-of-function mutations in the Drosophila Rap1 and Ras1 genes are described herein that interact genetically with fat facets mutations. Analysis of these genetic interactions reveals that Fat facets has an additional function later in eye development involving Rap1 and Ras1 proteins. Moreover, the results suggest that undifferentiated cells outside the facet continue to influence facet assembly later in eye development.
PubMed ID
PubMed Central ID
PMC25022 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference