Reference Report

Reference
Citation	Nestoras, K., Lee, H., Mohler, J. (1997). Role of knot (kn) in wing patterning in Drosophila. Genetics 147(3): 1203--1212. (Export to RIS)
FlyBase ID	FBrf0099419
Publication Type	Research paper
PubMed ID	9383063
PubMed Abstract	We have undertaken a genetic analysis of new strong alleles of knot (kn). The original kn1 mutation causes an alteration of wing patterning similar to that associated with mutations of fused (fu), an apparent fusion of veins 3 and 4 in the wing. However, unlike fu, strong kn mutations do not affect embryonic segmentation and indicate that kn is not a component of a general Hh (Hedgehog)-signaling pathway. Instead we find that kn has a specific role in those cells of the wing imaginal disc that are subject to ptc-mediated Hh-signaling. Our results suggest a model for patterning the medial portion of the Drosophila wing, whereby the separation of veins 3 and 4 is maintained by kn activation in the intervening region in response to Hh-signaling across the adjacent anterior-posterior compartment boundary.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (3)
	Df(2R)Jp1 Df(2R)trix In(2R)kn^SA1
Alleles (10)
	Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^ptc-H84 kn¹ kn^KN1 kn^KN2 kn^KN3 kn^KN4 kn^SA1 ptc^G20 ptc^S2
Constructs (1)
	P{BS3.0}
Genes (4)
	Ecol\lacZ kn L ptc
Insertions (1)
	P{A92}ptc^H84