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Sonnenfeld, M., Ward, M., Nystrom, G., Mosher, J., Stahl, S., Crews, S. (1997). The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development.  Development 124(22): 4571--4582.
FlyBase ID
FBrf0099730
Publication Type
Research paper
Abstract

The Drosophila single-minded and trachealess bHLH-PAS genes control transcription and development of the CNS midline cell lineage and tracheal tubules, respectively. We show that Single-minded and Trachealess activate transcription by forming dimers with the Drosophila Tango protein that is an orthologue of the mammalian Arnt protein. Both cell culture and in vivo studies show that a DNA enhancer element acts as a binding site for both Single- minded::Tango and Trachealess::Tango heterodimers and functions in controlling CNS midline and tracheal transcription. Isolation and analysis of tango mutants reveal CNS midline and tracheal defects, and gene dosage studies demonstrate in vivo interactions between single- minded::tango and trachealess::tango . These experiments support the existence of an evolutionarily conserved, functionally diverse bHLH-PAS protein regulatory system.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference
    Aberrations (1)
    Alleles (12)
    Genes (6)
    Physical Interactions (7)
    Insertions (6)
    Transgenic Constructs (1)
    Transcripts (1)