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Reference Report
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| Citation | Molina, I., Baars, S., Brill, J.A., Hales, K.G., Fuller, M.T., Ripoll, P. (1997). A chromatin-associated kinesin-related protein required for normal mitotic chromosome segregation in Drosophila. J. Cell Biol. 139(6): 1361--1371. (Export to RIS) | ||
| FlyBase ID | FBrf0099785 | ||
| Publication Type | Research paper | ||
| PubMed ID | 9396743 | ||
| PubMed Abstract | The tiovivo (tio) gene of Drosophila encodes a kinesin-related protein, KLP38B, that colocalizes with condensed chromatin during cell division. Wild-type function of the tio gene product KLP38B is required for normal chromosome segregation during mitosis. Mitotic cells in tio larval brains displayed circular mitotic figures, increased ploidy, and abnormal anaphase figures. KLP38B mRNA is maternally provided and expressed in cells about to undergo division. We propose that KLP38B, perhaps redundantly with other chromosome-associated microtubule motor proteins, contributes to interactions between chromosome arms and microtubules important for establishing bipolar attachment of chromosomes and assembly of stable bipolar spindles. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | J. Cell Biol. | ||
| Title | Journal of Cell Biology | ||
| Publication Year | 1966- | ||
| ISBN/ISSN | 0021-9525 | ||
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Data from Reference
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| Aberrations (2)
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| Alleles (4)
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| Genes (2)
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| Insertions (3)
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