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Citation	Larsson, J., Rasmuson-Lestander, A. (1997). Cloning, mapping and mutational analysis of the S-adenosylmethionine decarboxylase gene in Drosophila melanogaster. Molec. gen. Genet. 256(6): 652--660.
FlyBase ID	FBrf0099842
Type of publication	Research paper
Offprint Available	Yes
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PubMed ID	9435790
PubMed Abstract	S-adenosylmethionine decarboxylase is a key enzyme in the synthesis of polyamines. These small cationic molecules are required for growth and development in all organisms. A wealth of biological processes, including synthesis of DNA and protein and condensation of chromatin, involve polyamines. Inhibition of polyamine synthesis has been proposed for treatment of cancer but this requires more knowledge about the in vivo function of polyamines. We report here the cloning of the S-adenosylmethionine decarboxylase gene from Drosophila melanogaster and the analysis of corresponding mutants. The mutant phenotypes are similar to those previously described for ribosomal protein genes (Minutes) and rRNA genes (bobbed). This work elucidates the in vivo consequences of impaired polyamine synthesis with respect to the development of a whole animal.
Biosis	147300
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Language of publication	English
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Abbreviation	Molec. gen. Genet.
Title	Molecular and General Genetics
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Volume range	99-264
Year range	1967-2001
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Place of publication	Berlin
Language of publication	English
ISBN/ISSN	0026-8925
CODEN	MGGEAE
Data from Reference
Aberrations (6)
	Df(2L)J16 Df(2L)J17 Df(2L)J2 Df(2L)J3 Dp(?;2)bw^D In(1)w^m4
Alleles (6)
	SamDC^Scer\UAS.cLa SamDC^c SamDC^d SamDC^e Scer\GAL4^hs.PB w^+mC
Constructs (2)
	P{GAL4-Hsp70.PB} P{UAS-SamDC.L}
Genes (3)
	SamDC Scer\GAL4 w
Insertions (1)
	?{}SamDC^c