Reference Report

Reference
Citation	Sotillos, S., Roch, F., Campuzano, S. (1997). The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs. Development 124(23): 4769--4779. (Export to RIS)
FlyBase ID	FBrf0099884
Publication Type	Research paper
PubMed ID	9428413
PubMed Abstract	The Notch transmembrane protein is the receptor of an evolutionary conserved pathway that mediates intercellular signalling leading to the specification of different cell types during development. In this pathway, many aspects of the signal transduction mechanism remain poorly understood, especially the role of proteolytic processing of Notch. We present genetic evidence indicating that the metalloprotease-disintegrin kuzbanian (J. Rooke, D. Pan, T. Xu and G. M. Rubin (1996) Science 273, 1227-1231) is a new component of the Notch signalling pathway and is involved in Notch activation. kuzbanian genetic mosaics demonstrate that, during neurogenesis, wing margin formation and vein width specification kuzbanian is autonomously required in the cell where Notch is activated. Genetic interactions between kuzbanian and different genes of the Notch pathway indicate that kuzbanian is required upstream of Suppressor of Hairless. Moreover, the requirement of kuzbanian for signalling by a ligand-dependent Abruptex receptor, but not by a constitutively activated form of Notch, suggests that kuzbanian is involved in the generation of a Notch functional receptor and/or in its activation. However, differences in the phenotypes of loss-of-function Notch and kuzbanian mutations suggest the existence of alternative Kuzbanian-independent mechanisms that generate Notch functional receptors.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(2L)b88h49
Alleles (21)
	B4^k01405 B4^Scer\UAS.cSa E(spl)m8-HLH^Scer\UAS.cSa Ecol\lacZ^neur-A101 H² kuz^1405Rev4 kuz^1405Rev11 kuz^1405Rev23 kuz^H143 kuz^k01403 kuz^k01405 kuz^k07601 kuz^k11804 kuz^Scer\UAS.cFa N^55e11 N^Ax-16 N^Ax-M3 N^int.hs Scer\GAL4^C-765 Ser^D w^+mC
Constructs (4)
	P{hsp70-Notch.intra} P{UAS-B4.S} P{UAS-E(spl).S} P{UAS-kuz.F}
Genes (10)
	B4 E(spl)m8-HLH Ecol\lacZ H kuz N sc Scer\GAL4 Ser w
Insertions (9)
	P{?lacW}kuz^1405Rev4 P{?lacW}kuz^1405Rev11 P{?lacW}kuz^1405Rev23 P{GawB}C-765 P{lacW}kuz^k01403 P{lacW}kuz^k01405 P{lacW}kuz^k07601 P{lacW}kuz^k11804 P{lArB}neur^A101