Reference Report

Reference
Citation	Royet, J., Finkelstein, R. (1997). Establishing primordia in the Drosophila eye-antennal imaginal disc: the roles of decapentaplegic, wingless and hedgehog. Development 124(23): 4793--4800. (Export to RIS)
FlyBase ID	FBrf0099885
Publication Type	Research paper
PubMed ID	9428415
PubMed Abstract	The eye-antennal imaginal discs of Drosophila melanogaster form the head capsule of the adult fly. Unlike the limb primordia, each eye-antennal disc gives rise to morphologically and functionally distinct structures. As a result, these discs provide an excellent model system for determining how the fates of primordia are specified during development. In this study, we investigated how the adjacent primordia of the compound eye and dorsal head vertex are specified. We show that the genes wingless (wg) and orthodenticle (otd) are expressed throughout the entire second instar eye-antennal disc, conferring a default fate of dorsal vertex cuticle. Activation of decapentaplegic (dpp) expression in the posterior eye disc eliminates wg and otd expression, thereby permitting eye differentiation. We also demonstrate that otd is activated by wg in the vertex primordium. Finally, we show that early activation of dpp depends on hedgehog (hh) expression in the eye anlage prior to morphogenetic furrow formation.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (2)
	Df(2L)dpp^d14 In(2L)dpp^d12
Alleles (9)
	dpp^d-blk dsh⁴ Ecol\lacZ^arm.PV Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^hh-P30 hh^ts2 Mad^1-2 sgg³² so¹
Constructs (2)
	P{arm-lacZ.V} P{BS3.0}
Genes (9)
	dpp dsh Ecol\lacZ hh Mad oc sgg so wg
Insertions (1)
	P{PZ}hh^P30