Reference Report

Reference
Citation	Bezborodova, E., Kulikov, A., Georgiev, P. (1997). A new family of genes which, when mutated, suppress the inhibitory effect of the mod(mdg4)1u1 mutation on y2 expression in Drosophila melanogaster. Mol. Gen. Genet. 257(1): 83--90. (Export to RIS)
FlyBase ID	FBrf0099893
Publication Type	Research paper
PubMed ID	9439572
PubMed Abstract	The suppressor of Hairy-wing [su(Hw)] protein inhibits the function of transcriptional enhancers located distal to the promoter with respect to the location of su(Hw)-binding sites (insulation). Mutations in the modifier of mdg4 [mod(mdg4)] interfere with insulation and enhance the effect of the su(Hw)-binding region inserted in the y2 mutation by inhibiting the function of regulatory elements located on both sides of the su(Hw)-binding region. From P-M hybrid dysgenic crosses, 21 mutations that suppress the negative effect of the mod(mdg4)1u1 mutation on the y2 allele were obtained among 47,000 flies scored. These Su(mg) mutations have a dominant suppressor effect and map to at least 13 different loci. Some of Su(mg) mutations also suppress the effect of mod(mdg4)1u1 on two other gypsy-induced mutations, scD1 and ct6. Most of Su(mg) mutations do not affect the viability or fertility of homozygous flies. We speculate that the Su(mg) genes represent a new family of redundant regulatory genes in Drosophila melanogaster.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mol. Gen. Genet.
Title	Molecular and General Genetics
Publication Year	1967-2001
ISBN/ISSN	0026-8925
Data from Reference
Aberrations (1)
	In(1)w^m4
Alleles (35)
	ct⁶ ct^pN2s ct^pN30 e(y)1¹ e(y)2¹ mod(mdg4)^ul sc^D1 Su(mg)1-1^1-1 Su(mg)1-1^1-5 Su(mg)1-2^1-2 Su(mg)1-3^1-3 Su(mg)1-4^1-4 Su(mg)1-6^1-6 Su(mg)1-7^1-7 Su(mg)1-8^1-8 Su(mg)1-9^1-9 Su(mg)2-1^2-1 Su(mg)2-2^2-2 Su(mg)2-3^2-3 Su(mg)2-4^2-4 Su(mg)2-5^2-5 Su(mg)2-6^2-6 Su(mg)2-7^2-7 Su(mg)3-1^3-1 Su(mg)3-2^3-2 Su(mg)3-3^3-3 Su(mg)3-4^3-4 Su(mg)3-5^3-5 w^zm y² y^-700 y^-800 y⁺⁶⁶⁰ y^+2490R z¹
Constructs (4)
	P{y^-700} P{y^-800} P{y⁺⁶⁶⁰} P{y^+2490R}
Genes (29)
	ct e(y)1 e(y)2 f mod(mdg4) sc Su(mg)1-1 Su(mg)1-2 Su(mg)1-3 Su(mg)1-4 Su(mg)1-6 Su(mg)1-7 Su(mg)1-8 Su(mg)1-9 Su(mg)2-1 Su(mg)2-2 Su(mg)2-3 Su(mg)2-4 Su(mg)2-5 Su(mg)2-6 Su(mg)2-7 Su(mg)3-1 Su(mg)3-2 Su(mg)3-3 Su(mg)3-4 Su(mg)3-5 w y z