Subject: Helping FlyBase
Hi Lonny,
I'm just going through the 1997 abstract book for the CSH neurobiology
meeting and have a question for you. On page 78 you describe two adenyl
cyclase isoforms, 'DAC3' and 'DAC9'. FlyBase already has a gene for DAC9
(valid symbol Ac35C) but DAC3 is new to us. We have entries for
three genes that may correspond to DAC3:
\*a Ac34A
\*e Adenylyl cyclase 34A
\*z FBgn0004853
\*b 2-47
\*c 34A
\*x FBrf0078595 == ew1786 == Han and Davis, 1995, A. Conf. Dros. Res. 36: 91B
\*x FBrf0055565 == ewcell68.479f.mgUCLAKX == Levin et al., 1992, Cell 68: 479--489
\*F adenylate cyclase == EC 4.6.1.1
\*a Ac62D
\*e Adenylyl cyclase 62D
\*z FBgn0004851
\*b 3-1.5
\*c 62D
\*x FBrf0078595 == ew1786 == Han and Davis, 1995, A. Conf. Dros. Res. 36: 91B
\*x FBrf0055565 == ewcell68.479f.mgUCLAKX == Levin et al., 1992, Cell 68: 479--489
\*F adenylate cyclase == EC 4.6.1.1
\*a Ac76E
\*e Adenylyl cyclase 76E
\*z FBgn0004852
\*b 3-46
\*c 76E
\*x FBrf0078595 == ew1786 == Han and Davis, 1995, A. Conf. Dros. Res. 36: 91B
\*x FBrf0055565 == ewcell68.479f.mgUCLAKX == Levin et al., 1992, Cell 68: 479--489
\*F adenylate cyclase == EC 4.6.1.1
Do any of these encode DAC3? If not we will keep a new gene entry, Ac3
(with a synonym DAC3, we do not prefix Drosophila genes with a D), but if
so we will make the DAC3 entry under the appropriate gene.
With best wishes,
Rachel.
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Rachel Drysdale.
FlyBase (Cambridge),
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Subject: Re: Helping FlyBase
Dear Rachel,
DAC3 is distinct from the other Adenylyl cyclase genes already listed in
Flybase.
It has not yet been published. We have deposited its sequence into GENBANK,
but it has not been released yet (we are awaiting its publication).
For the sake of completeness, it maps to the interval 39E5-F3.
While you are updating the AC entries in Flybase, would you please add the
synonym 'DAC2' to the entry for Ac76E....we have completed cloning this
cyclase and it is most closely related to mammalian AC2. As with the others
I have mentioned, we are not quite ready to publish the cloning of this AC,
but it would be nice for Flybase to be as up-to-date as we are.
Thanks again.
lrl
_____________________________________________ _______
Lonny R. Levin
Department of Pharmacology
Cornell University Medical College
1300 York Avenue Rm. E-505
New York, NY 10021
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