Reference Report

Reference
Citation	Pignoni, F., Hu, B., Zavitz, K.H., Xiao, J., Garrity, P.A., Zipursky, S.L. (1997). The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. Cell 91(7): 881--891. (Export to RIS)
FlyBase ID	FBrf0100207
Publication Type	Research paper
PubMed ID	9428512
PubMed Abstract	Sine oculis (so) and eyes absent (eya) are required for Drosophila eye development and are founding members of the mammalian Six and Eya gene families. These genes have been proposed to act with eyeless (Pax6) to regulate eye development in vertebrates and invertebrates. so encodes a highly diverged homeobox transcription factor and eya encodes a novel nuclear protein. We demonstrate that So and Eya (1) regulate common steps in eye development including cell proliferation, patterning, and neuronal development; (2) synergize in inducing ectopic eyes; and (3) interact in yeast and in vitro through evolutionarily conserved domains. We propose that an So/Eya complex regulates multiple steps in eye development and functions within the context of a network of genes to specify eye tissue identity.
DOI
Related Publication(s)
Erratum	The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. Pignoni et al., 1998, Cell 92(4): 587 [FBrf0100804]
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (15)
	Ecol\lacZ^D.HZ50 Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^Scer\UAS.cUa ey² eya² eya^cli-IID eya^Scer\UAS.cPa phyl^unspecified Scer\FLP1^GMR.PP Scer\GAL4^dpp.blk1 Scer\GAL4^upd-E132 so¹ so³ so^Scer\UAS.cPa w^+mC
Constructs (7)
	P{(-GMR)lacZ.D} P{BS3.0} P{GAL4-dpp.blk1} P{GMR-FLP1.P} P{UAS-eya.P} P{UAS-lacZ.U} P{UAS-so.P}
Genes (10)
	dac Ecol\lacZ elav ey eya phyl Scer\FLP1 Scer\GAL4 so w
Insertions (1)
	P{GawB}E132