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Pignoni, F., Hu, B., Zavitz, K.H., Xiao, J., Garrity, P.A., Zipursky, S.L. (1997). The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development.  Cell 91(7): 881--891.
FlyBase ID
FBrf0100207
Publication Type
Research paper
Abstract

Sine oculis (so) and eyes absent (eya) are required for Drosophila eye development and are founding members of the mammalian Six and Eya gene families. These genes have been proposed to act with eyeless (Pax6) to regulate eye development in vertebrates and invertebrates. so encodes a highly diverged homeobox transcription factor and eya encodes a novel nuclear protein. We demonstrate that So and Eya (1) regulate common steps in eye development including cell proliferation, patterning, and neuronal development; (2) synergize in inducing ectopic eyes; and (3) interact in yeast and in vitro through evolutionarily conserved domains. We propose that an So/Eya complex regulates multiple steps in eye development and functions within the context of a network of genes to specify eye tissue identity.

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Erratum

The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development.
Pignoni et al., 1998, Cell 92(4): 587 [FBrf0100804]

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Alleles (15)
    Genes (10)
    Insertions (1)
    Experimental Tools (3)
    Transgenic Constructs (7)