Reference Report

Reference
Citation	Hacohen, N., Kramer, S., Sutherland, D., Hiromi, Y., Krasnow, M.A. (1998). sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell 92(2): 253--263. (Export to RIS)
FlyBase ID	FBrf0100567
Publication Type	Research paper
PubMed ID	9458049
PubMed Abstract	Antagonists of several growth factor signaling pathways play important roles in developmental patterning by limiting the range of the cognate inducer. Here, we describe an antagonist of FGF signaling that patterns apical branching of the Drosophila airways. In wild-type embryos, the Branchless FGF induces secondary branching by activating the Breathless FGF receptor near the tips of growing primary branches. In sprouty mutants, the FGF pathway is overactive and ectopic branches are induced on the stalks of primary branches. We show that FGF signaling induces sprouty expression in the nearby tip cells, and sprouty acts nonautonomously and in a competitive fashion to block signaling to the more distant stalk cells. sprouty encodes a novel cysteine-rich protein that defines a new family of putative signaling molecules that may similarly function as FGF antagonists in vertebrate development.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (6)
	Df(3L)1226 Df(3L)1227 Df(3L)H99 Df(3L)HR119 Df(3L)HR232 Df(3L)HR298
Alleles (31)
	bnl^Scer\UAS.cSa btl^LG19 Ecol\lacZ^aop-A141 Ecol\lacZ^bs-03267 Ecol\lacZ^btl-6-81 Ecol\lacZ^Lam-02459 Ecol\lacZ^pnt-07825 Ecol\lacZ^stg.β Ecol\lacZ^sty-09143 Ecol\lacZ^sty-s1814 Ecol\lacZ^sty-s2683 Ecol\lacZ^sty-Δ55 Ecol\lacZ^Terminal-2 Ecol\lacZ^Terminal-3 Ecol\lacZ^trh-1-eve-1 Ecol\lacZ^Ubx.35UZ l(3)09143⁰⁹¹⁴³ pnt^P1.Scer\UAS pnt^Δ88 Scer\GAL4^C38 Scer\GAL4^hs.2sev sty²¹¹ sty²²⁶ sty²⁵⁴ sty^F7 sty^G5 sty^Scer\UAS.cHa sty^Δ5 sty^Δ55 sty^Δ64 w^+mC
Constructs (6)
	P{35UZ} P{GAL4-Hsp70.sev} P{stg-lacZ.β} P{UAS-bnl.S} P{UAS-pnt.P1} P{UAS-sty.H}
Genes (11)
	aop bnl bs btl Ecol\lacZ l(3)09143 N pnt Scer\GAL4 sty w
Insertions (14)
	P{ET-L}trh-1-eve-1 P{GawB}C38 P{GawB}tracheal P{lacW}btl^6-81 P{lacW}s1814 P{lacW}s2683 P{lacW}sty^Δ55 P{lacZ}Terminal-2 P{lacZ}Terminal-3 P{lwB}aop^A141 P{PZ}bs⁰³²⁶⁷ P{PZ}eIF5B⁰⁹¹⁴³ P{PZ}Lam⁰²⁴⁵⁹ P{PZ}pnt⁰⁷⁸²⁵