Reference Report

Reference
Citation	Li, H., Baker, B.S. (1998). Her, a gene required for sexual differentiation in Drosophila, encodes a zinc finger protein with characteristics of ZFY-like proteins and is expressed independently of the sex determination hierarchy. Development 125(2): 225--235. (Export to RIS)
FlyBase ID	FBrf0100594
Publication Type	Research paper
PubMed ID	9486796
PubMed Abstract	The zygotic function of the hermaphrodite (her) gene of Drosophila plays an important role in sexual differentiation. Our molecular genetic characterization of her suggests that her is expressed sex non-specifically and independently of other known sex determination genes and that it acts together with the last genes in the sex determination hierarchy, doublesex and intersex, to control female sexual differentiation. Consistent with such a terminal function in sexual differentiation, her encodes a protein with C2H2-type zinc fingers. The her zinc fingers are atypical and similar to the even-numbered zinc fingers of ZFY and ZFX proteins in humans and other vertebrates.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (9)
	Df(2L)H20 Df(2L)her⁸ Df(2L)r10 Df(2L)RI1 Df(2L)RM5 Df(2L)RN2 Df(2L)TE35D-16 Df(2L)TE35D-18 In(2L)her^mat-1
Alleles (14)
	cact²⁵⁵ grp^lemp-8 grp^lemp-B17 grp^lemp-B17dX grp^lemp-H10 grp^lemp-mat-1 her¹ her³ her⁸ her^+t10 her^+t17 her^hs.PL her^mat-1 w^+mC
Constructs (4)
	P{her.B17} P{her.H10} P{hs-her.L} P{lemp.B17dX}
Genes (10)
	cact dsx fru grp her ix Sxl tra tra2 w
Insertions (1)
	P{FZ}cact²⁵⁵