Reference Report

Reference
Citation	Mallin, D.R., Myung, J.S., Patton, J.S., Geyer, P.K. (1998). Polycomb group repression is blocked by the Drosophila suppressor of Hairy-wing [su(Hw)] insulator. Genetics 148(1): 331--339. (Export to RIS)
FlyBase ID	FBrf0100598
Publication Type	Research paper
PubMed ID	9475743
PubMed Abstract	The suppressor of Hairy-wing [SU(HW)] binding region disrupts communication between a large number of enhancers and promoters and protects transgenes from chromosomal position effects. These properties classify the SU(HW) binding region as an insulator. While enhancers are blocked in a general manner, protection from repressors appears to be more variable. In these studies, we address whether repression resulting from the Polycomb group genes can be blocked by the SU(HW) binding region. The effects of this binding region on repression established by an Ultrabithorax Polycomb group Response Element were examined. A transposon carrying two reporter genes, the yellow and white genes, was used so that repression and insulation could be assayed simultaneously. We demonstrate that the SU(HW) binding region is effective at preventing Polycomb group repression. These studies suggest that one role of the su(Hw) protein may be to restrict the range of action of repressors, such as the Polycomb group proteins, throughout the euchromatic regions of the genome.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Alleles (12)
	Asx³ gypsy\su(Hw)BR⁴³⁰ Pc³ Pcl⁵ Psc¹ Sce^D1 Scm^D1 su(Hw)⁷ su(Hw)^V UbxPRE^1.6 w^BR.E.BR y^+mDint2
Constructs (3)
	P{SUPor-P.PRE#2} P{SUPor-P.PRE#6} P{SUPor-P}
Genes (11)
	Asx gypsy\su(Hw)BR Pc Pcl Psc Sce Scm su(Hw) UbxPRE w y
Insertions (9)
	P{SUPor-P.PRE#2}9M2 P{SUPor-P.PRE#6}4 P{SUPor-P.PRE#6}69 P{SUPor-P.PRE#6}69M1 P{SUPor-P.PRE#6}69M2 P{SUPor-P.PRE#6}69M3 P{SUPor-P.PRE#6}69M6 P{SUPor-P.PRE#6}69M7 P{SUPor-P.PRE#6}69M10