Reference Report

Reference
Citation	Yu, H.H., Araj, H.H., Ralls, S.A., Kolodkin, A.L. (1998). The transmembrane Semaphorin Sema I is required in Drosophila for embryonic motor and CNS axon guidance. Neuron 20(2): 207--220. (Export to RIS)
FlyBase ID	FBrf0100649
Publication Type	Research paper
PubMed ID	9491983
PubMed Abstract	The semaphorins comprise a large family of conserved glycoproteins, several members of which have been shown to function in repulsive neuronal growth cone guidance. We show here that Drosophila Semaphorin I (Sema I), a transmembrane semaphorin expressed on embryonic motor and CNS axons, is required for correct guidance of motor axons and for the formation of CNS pathways. In mutant embryos lacking Sema I, motor axons stall and fail to defasciculate at specific choice points where normally they would project to their muscle targets. In addition, a specific CNS fascicle fails to form correctly in these embryos. Rescue and ectopic expression experiments show that Sema I is required in neurons to mediate axon guidance decisions. These studies further suggest that like secreted semaphorins, transmembrane semaphorins can function as repulsive guidance cues for specific axon guidance events during neurodevelopment.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (2)
	Df(2L)N22-3 Df(2L)N22-5
Alleles (9)
	Ecol\lacZ^{Sema-1a-k13702} Scer\GAL4^elav-C155 Scer\GAL4^how-24B Scer\GAL4^sca-537.4 Sema-1a^EC.Scer\UAS Sema-1a^k03509 Sema-1a^k13702 Sema-1a^Scer\UAS.cYa w^+mC
Constructs (2)
	P{UAS-sema-I.EC} P{UAS-sema-I.Y}
Genes (8)
	Ecol\lacZ en eve Fas2 Fas3 Scer\GAL4 Sema-1a w
Insertions (5)
	P{GawB}elav^C155 P{GawB}how^24B P{GawB}sca^537.4 P{lacW}Sema-1a^k03509 P{lacW}Sema-1a^k13702