|
Reference
|
| Citation |
Kaufmann, N., Wills, Z.P., Van Vactor, D. (1998). Drosophila Rac1 controls motor axon guidance. Development 125(3): 453--461. |
| FlyBase ID |
FBrf0100716 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
|
External Crossreferences
|
| PubMed ID |
9425140 |
| PubMed Abstract |
Previous genetic studies of intersegmental nerve b development have identified several cell-surface proteins required for
correct axon guidance to appropriate target muscles. Here we provide evidence that the small GTPase Drac1 also plays a key
role in this guidance process. Neuronal expression of the dominant negative mutation Drac1(N17) causes axons to bypass and
extend beyond normal synaptic partners. This phenotype is consistently reproduced by pharmacological blockade of actin assembly.
Genetic interactions between Drac1(N17) and the receptor-tyrosine phosphatase Dlar suggest that intersegmental nerve b guidance
requires the integration of multiple, convergent signals.
|
| Biosis |
1179873 |
| Zoological record |
|
Associated Information
|
| Comments |
|
| Text of personal communication |
|
| Associated files |
|
|
Related Publications
|
|
|
|
Also Published As
|
|
|
|
Other Reference Information
|
| Secondary IDs |
|
| Language of publication |
English |
| Additional language(s) of abstract |
|
| ISBN |
|
| Place of publication |
|
|
Published In
|
| Abbreviation |
Development |
| Title |
Development |
| Authors |
|
| Volume range |
99- |
| Year range |
1987- |
| Page range |
|
| Publisher |
|
| Place of publication |
Cambridge |
| Language of publication |
English |
| ISBN/ISSN |
0950-1991 |
| CODEN |
DEVPED |
|
Data from Reference
|
| Alleles (13)
|
|
|
| Constructs (6)
|
|
|
| Genes (7)
|
|
|
| Insertions (2)
|
|
|
|
Home