|
Reference
|
| Citation |
Broihier, H.T., Moore, L.A., Van Doren, M., Newman, S., Lehmann, R. (1998). zfh-1 is required for germ cell migration and gonadal mesoderm development in Drosophila. Development 125(4): 655--666. |
| FlyBase ID |
FBrf0100750 |
| Type of publication |
Research paper |
| Offprint Available |
No |
|
External Crossreferences
|
| PubMed ID |
9435286 |
| PubMed Abstract |
In Drosophila as well as many vertebrate systems, germ cells form extraembryonically and migrate into the embryo before navigating
toward gonadal mesodermal cells. How the gonadal mesoderm attracts migratory germ cells is not understood in any system. We
have taken a genetic approach to identify genes required for germ cell migration in Drosophila. Here we describe the role
of zfh-1 in germ cell migration to the gonadal mesoderm. In zfh-1 mutant embryos, the initial association of germ cells and
gonadal mesoderm is blocked. Loss of zfh-1 activity disrupts the development of two distinct mesodermal populations: the caudal
visceral mesoderm and the gonadal mesoderm. We demonstrate that the caudal visceral mesoderm facilitates the migration of
germ cells from the endoderm to the mesoderm. Zfh-1 is also expressed in the gonadal mesoderm throughout the development of
this tissue. Ectopic expression of Zfh-1 is sufficient to induce additional gonadal mesodermal cells and to alter the temporal
course of gene expression within these cells. Finally, through analysis of a tinman zfh-1 double mutant, we show that zfh-1
acts in conjunction with tinman, another homeodomain protein, in the specification of lateral mesodermal derivatives, including
the gonadal mesoderm.
|
| Biosis |
1208367 |
| Zoological record |
|
Associated Information
|
| Comments |
|
| Text of personal communication |
|
| Associated files |
|
|
Related Publications
|
|
|
|
Also Published As
|
|
|
|
Other Reference Information
|
| Secondary IDs |
|
| Language of publication |
English |
| Additional language(s) of abstract |
|
| ISBN |
|
| Place of publication |
|
|
Published In
|
| Abbreviation |
Development |
| Title |
Development |
| Authors |
|
| Volume range |
99- |
| Year range |
1987- |
| Page range |
|
| Publisher |
|
| Place of publication |
Cambridge |
| Language of publication |
English |
| ISBN/ISSN |
0950-1991 |
| CODEN |
DEVPED |
|
Data from Reference
|
| Aberrations (4)
|
|
|
| Alleles (10)
|
|
|
| Constructs (1)
|
|
|
| Genes (10)
|
|
|
| Natural transposons (1)
|
|
|
|
Home