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Reference
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| Citation |
O'Hare, K., Tam, J.L., Lim, J.K., Yurchenko, N.N., Zakharov, I.K. (1998). Rearrangements at a hobo element inserted into the first intron of the singed gene in the unstable sn[49] system of Drosophila
melanogaster. Molec. gen. Genet. 257(4): 452--460.
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| FlyBase ID |
FBrf0101971 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
9529526 |
| PubMed Abstract |
The cytological structure of the X chromosome and the DNA organisation of the singed locus were examined in five singed bristle
mutants of Drosophila melanogaster. These mutants are all derived from the unstable mutant singed-49, isolated from a wild
population in the Russian Far East in 1975. Rearrangements were found at a site within the first intron of the singed gene,
where a hobo element is inserted in these mutants. One rearrangement, which is associated with a strong bristle phenotype,
has an inversion between 2D and the location of singed at 7D, which separates the singed promoter from the singed coding region.
Two phenotypically wild-type derivatives have smaller rearrangements within the first intron which do not appear to interfere
with singed expression. Two derivatives with bristle phenotypes have more complex rearrangements, and one of them shows a
dominant or antimorphic phenotype. DNA blotting and in situ hybridisation experiments show that, in addition to these rearrangements
at a hobo element inserted at singed, other hobo elements in these strains have been mobilised. This system is therefore similar
to others in which functional hobo elements continue to transpose, resulting in elevated rates of mutation and chromosome
rearrangement.
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| Biosis |
1179937 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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| Associated files |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Molec. gen. Genet. |
| Title |
Molecular and General Genetics |
| Authors |
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| Volume range |
99-264 |
| Year range |
1967-2001 |
| Page range |
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| Publisher |
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| Place of publication |
Berlin |
| Language of publication |
English |
| ISBN/ISSN |
0026-8925 |
| CODEN |
MGGEAE |
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Data from Reference
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| Aberrations (1)
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| Alleles (8)
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| Genes (1)
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| Insertions (2)
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