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Citation
Schnepp, B., Donaldson, T., Grumbling, G., Ostrowski, S., Schweitzer, R., Shilo, B.Z., Simcox, A. (1998). EGF domain swap converts a Drosophila EGF receptor activator into an inhibitor.  Genes Dev. 12(7): 908--913.
FlyBase ID
FBrf0102005
Publication Type
Research paper
Abstract

In Drosophila the function of the epidermal growth factor (EGF) receptor is modulated zygotically by three EGF-like proteins: Spitz (Spi), which is a potent activator; Vein (Vn), which is a moderate activator; and Argos (Aos), which is an inhibitor. Chimeric molecules were constructed in which the EGF domain of Vn was swapped with the EGF domain from each factor. The modified Vn proteins behaved both in vitro and in vivo with properties characteristic of the factor from which the EGF domain was derived. These results demonstrate that the EGF domain is the key determinant that gives DER inhibitors and activators their distinct properties.

PubMed ID
PubMed Central ID
PMC316677 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference