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Ip, Y.T., Davis, R.J. (1998). Signal transduction by the c-Jun N-terminal kinase (JNK) - from inflammation to development.  Curr. Opin. Cell Biol. 10(2): 205--219.
FlyBase ID
FBrf0102168
Publication Type
Review
Abstract

The c-Jun amino-terminal kinase (JNK) group of MAP kinases has been identified in mammals and insects. JNK is activated by exposure of cells to cytokines or environmental stress, indicating that this signaling pathway may contribute to inflammatory responses. Genetic and biochemical studies demonstrate that this signaling pathway also regulates cellular proliferation, apoptosis, and tissue morphogenesis. A functional role for JNK is therefore established in both the cellular response to stress and in many normal physiological processes.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Opin. Cell Biol.
    Title
    Current Opinion in Cell Biology
    Publication Year
    1989-
    ISBN/ISSN
    0955-0674
    Data From Reference
    Genes (17)