Reference Report

Reference
Citation	Lo, P.C.H., Frasch, M. (1998). bagpipe-dependent expression of vimar, a novel armadillo-repeats gene, in Drosophila visceral mesoderm. Mech. Dev. 72(1,2): 65--75. (Export to RIS)
FlyBase ID	FBrf0102180
Publication Type	Research paper
PubMed ID	9533953
PubMed Abstract	Two homeobox-containing genes, tinman and bagpipe, play important roles during the specification of the midgut visceral musculature from the mesoderm during Drosophila embryogenesis. Expression of tinman in the dorsal mesoderm activates the expression of the bagpipe gene in segmental subsets of those cells, which then become determined to form the midgut visceral mesoderm. Understanding how the bagpipe gene affects this specification requires the isolation and characterization of its downstream target genes. Using an enhancer trap line that expresses its marker in the midgut visceral mesoderm, we have cloned and characterized a novel gene (vimar) that is expressed embryonically in the mid and hindgut visceral mesoderm, as well as in the CNS and PNS. The expression of this gene in the midgut visceral mesoderm initiates shortly after bagpipe expression and depends on bagpipe function. Maternal and zygotic transcripts are produced from this gene by alternative polyadenylation, and encode the same 634-amino acid protein. The vimar protein contains 15 tandem copies of the Armadillo repeat, a protein interaction domain, and is similar to mammalian Smg guanine dissociation stimulator protein, which stimulates the activity of a number of different p21 small G-proteins. These results, together with the observed lethality of vimar mutations, indicate that vimar is one of the bagpipe target genes that are required for normal development and differentiation of the midgut visceral mesoderm.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (5)
	Df(2R)cn88b Df(2R)Drl^rv7 Df(2R)Drl^rv17 Df(2R)Drl^rv28 Df(3R)e-D7
Alleles (4)
	Ecol\lacZ^{vimar-B6-2-30} tin^+t10.7 vimar^B6-2-30 vimar^F39-167
Constructs (1)
	P{CaSperRe28}
Genes (5)
	bap Ecol\lacZ Fas3 tin vimar
Insertions (2)
	P{lacW}vimar^B6-2-30 P{lacW}vimar^k16722
Transcripts (1)
	vimar-RB