Reference Report

Reference
Citation	Giniger, E. (1998). A role for Abl in Notch signaling. Neuron 20(4): 667--681. (Export to RIS)
FlyBase ID	FBrf0102318
Publication Type	Research paper
External Crossreferences
PubMed ID	9581760
PubMed Abstract	Abl is an axonal tyrosine kinase that has yet to be clearly linked to a receptor; Notch is a receptor for which the signaling pathway remains incompletely understood. We show here that Notch and abl mutations interact synergistically to produce synthetic lethality and defects in axon extension. Surprisingly, we cannot account for these axonal aberrations on the basis of changes in cell identity. We show, moreover, that Notch is present in the growth cones of extending axons, and that the Abl accessory protein Disabled binds to a signaling domain of Notch in vitro. We therefore speculate that Disabled and Abl may play a role in Notch signaling in Drosophila axons, perhaps by binding to the Notch intracellular domain.
BIOSIS ID	1251916
Zoological Record ID
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
ISBN
Parent Publication
Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Editors
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (4)
	Df(1)N-8 Df(3L)st-j7 Dp(1;Y)w^-N⁺ In(3L)std11
Alleles (9)
	Abl¹ Abl² Abl^+mTnabl Ecol\lacZ^KZ636 N^55e11 N^l1N-ts1 N^Scer\UAS.cBa Nrt^M54 Scer\GAL4^elav.PLu
Constructs (3)
	P{Abl.G} P{GAL4-elav.L} P{UAS-N.Ba}
Genes (14)
	Abl Dab Ecol\lacZ elav eve Fas2 ftz N Nrt numb odd pros Scer\GAL4 w
Insertions (1)
	P{KZ.TRAP}KZ636