Reference Report

Reference
Citation	Winberg, M.L., Mitchell, K.J., Goodman, C.S. (1998). Genetic analysis of the mechanisms controlling target selection: complementary and combinatorial functions of netrins, semaphorins, and IgCAMs. Cell 93(4): 581--591. (Export to RIS)
FlyBase ID	FBrf0102605
Publication Type	Research paper
PubMed ID	9604933
PubMed Abstract	The molecular mechanisms controlling the ability of motor axons to recognize their appropriate muscle targets were dissected using Drosophila genetics to add or subtract Netrin A, Netrin B, Semaphorin II, and Fasciclin II alone or in combination. Fas II and Sema II are expressed by all muscles where they promote (Fas II) or inhibit (Sema II) promiscuous synaptogenesis. NetB is expressed by a subset of muscles where it attracts some axons and repels others. However, growth cones in this system apparently do not rely solely on single molecular labels on individual targets. Rather, these growth cones assess the relative balance of attractive and repulsive forces and select their targets based on the combinatorial and simultaneous input of multiple cues.
DOI
Related Publication(s)
Review	Paper alert. Anonymous, 1998, Curr. Opin. Neurobiol. 8(4): 432 [FBrf0112191]
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (3)
	T(1;Y)B118 T(1;Y)T9 Ts(1Lt;YSt)B118+Ts(1Rt;YLt)T9
Alleles (16)
	Fas2^Scer\UAS.cLb fra³ fra⁴ NetA^{hs.sli.T:Hsap\MYC} NetA^Scer\UAS.cHa NetB^{hs.sli.T:Hsap\MYC} NetB^Scer\UAS.cHa Scer\GAL4^A51 Scer\GAL4^F63 Scer\GAL4^how-24B Scer\GAL4^l(3)H94-H94 Sema-2a⁰³⁰²¹ Sema-2a⁰³⁴⁷⁴ Sema-2a^ex59 Sema-2a^hs.Tl Sema-2a^Scer\UAS.cKa
Constructs (7)
	P{pCaSpeR-Toll-semaII} P{slit-NetA} P{slit-NetB} P{UAS-Fas2.PEST+} P{UAS-NETA} P{UAS-NETB} P{UAS-sema-II.K}
Genes (8)
	Fas2 fra NetA NetB rut Scer\GAL4 Sema-2a T:Hsap\MYC
Insertions (6)
	P{GAL4}F63 P{GawB}A51 P{GawB}how^24B P{GawB}l(3)H94^H94 P{PZ}Sema-2a⁰³⁰²¹ P{PZ}Sema-2a⁰³⁴⁷⁴