Reference Report

Reference
Citation	Wisotzkey, R.G., Mehra, A., Sutherland, D.J., Dobens, L.L., Liu, X., Dohrmann, C., Attisano, L., Raftery, L.A. (1998). Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses. Development 125(8): 1433--1445. (Export to RIS)
FlyBase ID	FBrf0102610
Publication Type	Research paper
PubMed ID	9502724
PubMed Abstract	Mothers against dpp (Mad) mediates Decapentaplegic (DPP) signaling throughout Drosophila development. Here we demonstrate that Medea encodes a MAD-related protein that functions in DPP signaling. MEDEA is most similar to mammalian Smad4 and forms heteromeric complexes with MAD. Like dpp, Medea is essential for embryonic dorsal/ventral patterning. However, Mad is essential in the germline for oogenesis whereas Medea is dispensable. In the wing primordium, loss of Medea most severely affects regions receiving low DPP signal. MEDEA is localized in the cytoplasm, is not regulated by phosphorylation, and requires physical association with MAD for nuclear translocation. Furthermore, inactivating MEDEA mutations prevent nuclear translocation either by preventing interaction with MAD or by trapping MAD/MEDEA complexes in the cytosol. Thus MAD-mediated nuclear translocation is essential for MEDEA function. Together these data show that, while MAD is essential for mediating all DPP signals, heteromeric MAD/MEDEA complexes function to modify or enhance DPP responses. We propose that this provides a general model for Smad4/MEDEA function in signaling by the TGF-beta family.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (10)
	Df(3R)awd-KRB Df(3R)E40 Df(3R)E(sina)9 Df(3R)faf-BP Df(3R)Kpn-A Df(3R)tll-g Df(3R)ttk-Δ1 Df(3R)ttk-Δ2 Df(3R)ttk-Δ3 Df(3R)X3F
Alleles (17)
	dpp^H47 dpp^Scer\UAS.cSa Ecol\lacZ^arm.PV Ecol\lacZ^bi-Pol-1 Ecol\lacZ^dpp.RD2 Ecol\lacZ^Ubx.35UZ Mad¹² Mad^{Ubi-p63E.T:Hsap\MYC} Med¹ Med² Med³ Med⁴ Med⁵ Med⁶ Med⁷ Med⁸ Scer\GAL4^how-24B
Constructs (5)
	P{35UZ} P{arm-lacZ.V} P{dpp^shv-lacZ.RD2} P{UAS-dpp.S} P{UmMad}
Genes (12)
	ca dpp Ecol\lacZ faf lab Mad Med rod Scer\GAL4 T:Hsap\MYC tkv ttk
Insertions (2)
	P{GawB}how^24B P{lacW}bi^Pol-1