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Reference
Citation	Wisotzkey, R.G., Mehra, A., Sutherland, D.J., Dobens, L.L., Liu, X., Dohrmann, C., Attisano, L., Raftery, L.A. (1998). Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses. Development 125(8): 1433--1445.
FlyBase ID	FBrf0102610
Type of publication	Research paper
Offprint Available	No
External Crossreferences
PubMed ID	9502724
PubMed Abstract	Mothers against dpp (Mad) mediates Decapentaplegic (DPP) signaling throughout Drosophila development. Here we demonstrate that Medea encodes a MAD-related protein that functions in DPP signaling. MEDEA is most similar to mammalian Smad4 and forms heteromeric complexes with MAD. Like dpp, Medea is essential for embryonic dorsal/ventral patterning. However, Mad is essential in the germline for oogenesis whereas Medea is dispensable. In the wing primordium, loss of Medea most severely affects regions receiving low DPP signal. MEDEA is localized in the cytoplasm, is not regulated by phosphorylation, and requires physical association with MAD for nuclear translocation. Furthermore, inactivating MEDEA mutations prevent nuclear translocation either by preventing interaction with MAD or by trapping MAD/MEDEA complexes in the cytosol. Thus MAD-mediated nuclear translocation is essential for MEDEA function. Together these data show that, while MAD is essential for mediating all DPP signals, heteromeric MAD/MEDEA complexes function to modify or enhance DPP responses. We propose that this provides a general model for Smad4/MEDEA function in signaling by the TGF-beta family.
Biosis	1302397
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Language of publication	English
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Abbreviation	Development
Title	Development
Authors
Volume range	99-
Year range	1987-
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Place of publication	Cambridge
Language of publication	English
ISBN/ISSN	0950-1991
CODEN	DEVPED
Data from Reference
Aberrations (10)
	Df(3R)E(sina)9 Df(3R)E40 Df(3R)Kpn-A Df(3R)X3F Df(3R)awd-KRB Df(3R)faf-BP Df(3R)tll-g Df(3R)ttk-Δ1 Df(3R)ttk-Δ2 Df(3R)ttk-Δ3
Alleles (17)
	Ecol\lacZ^Ubx.35UZ Ecol\lacZ^arm.PV Ecol\lacZ^bi-Pol-1 Ecol\lacZ^dpp.RD2 Mad¹² Mad^{Ubi-p63E.T:Hsap\MYC} Med¹ Med² Med³ Med⁴ Med⁵ Med⁶ Med⁷ Med⁸ Scer\GAL4^how-24B dpp^H47 dpp^Scer\UAS.cSa
Constructs (5)
	P{35UZ} P{UAS-dpp.S} P{UmMad} P{arm-lacZ.V} P{dpp^shv-lacZ.RD2}
Genes (12)
	Ecol\lacZ Mad Med Scer\GAL4 T:Hsap\MYC ca dpp faf lab rod tkv ttk
Insertions (2)
	P{GawB}how^24B P{lacW}bi^Pol-1