Reference Report

Reference
Citation	Das, P., Maduzia, L.L., Wang, H., Finelli, A.L., Cho, S.H., Smith, M.M., Padgett, R.W. (1998). The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling. Development 125(8): 1519--1528. (Export to RIS)
FlyBase ID	FBrf0102615
Publication Type	Research paper
PubMed ID	9502733
PubMed Abstract	Signals from transforming growth factor-beta (TGF-beta) ligands are transmitted within the cell by members of the Smad family, which can be grouped into three classes based on sequence similarities. Our previous identification of both class I and II Smads functioning in a single pathway in C. elegans, raised the issue of whether the requirement for Smads derived from different classes is a general feature of TGF-beta signaling. We report here the identification of a new Drosophila class II Smad, Medea, a close homolog of the human tumor-suppressor gene DPC4. Embryos from germline clones of both Medea and Mad (a class I Smad) are ventralized, as are embryos null for the TGF-beta-like ligand decapentaplegic (dpp). Loss of Medea also blocks dpp signaling during later development, suggesting that Medea, like Mad, is universally required for dpp signaling. Furthermore, we show that the necessity for these two closely related, non-redundant Smads, is due to their different signaling properties - upon activation of the Dpp pathway, Mad is required to actively translocate Medea into the nucleus. These results provide a paradigm for, and distinguish between, the requirement for class I and II Smads in Dpp/BMP signaling.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(3R)E40
Alleles (26)
	dpp^H48 dpp^H61 dpp^hr27 dpp^MtnA.PD Mad¹⁰ Mad¹² Mad^{MtnA.T:Zzzz\FLAG} Mad^{Ubi-p63E.T:Hsap\MYC} Med¹ Med¹⁹ Med²¹ Med²² Med²³ Med²⁵ Med²⁶ Med²⁷ Med^{MtnA.T:Ivir\HA1} Med^Ubi-p63E.PD Med^unspecified put^MtnA.PD sax^{Q263D.Scer\UAS.cDa} Scer\GAL4^en-e16E tkv^MtnA.PD tkv^Q199D.MtnA tkv^SC143 tkv^Ubi-p63E.PB
Constructs (4)
	P{UAS-sax.Q263D.D} P{Ubi-p63E-Med.D} P{Ubi-tkv-1} P{UmMad}
Genes (10)
	dpp Mad Med put sax Scer\GAL4 T:Hsap\MYC T:Ivir\HA1 T:Zzzz\FLAG tkv
Insertions (1)
	P{en2.4-GAL4}e16E