Reference Report

Reference
Citation	Cadigan, K.M., Fish, M.P., Rulifson, E.J., Nusse, R. (1998). Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing. Cell 93(5): 767--777. (Export to RIS)
FlyBase ID	FBrf0102726
Publication Type	Research paper
PubMed ID	9630221
PubMed Abstract	In Drosophila wing imaginal discs, the Wingless (Wg) protein acts as a morphogen, emanating from the dorsal/ventral (D/V) boundary of the disc to directly define cell identities along the D/V axis at short and long range. Here, we show that high levels of a Wg receptor, Drosophila frizzled 2 (Dfz2), stabilize Wg, allowing it to reach cells far from its site of synthesis. Wg signaling represses Dfz2 expression, creating a gradient of decreasing Wg stability moving toward the D/V boundary. This repression of Dfz2 is crucial for the normal shape of Wg morphogen gradient as well as the response of cells to the Wg signal. In contrast to other ligand-receptor relationships where the receptor limits diffusion of the ligand, Dfz2 broadens the range of Wg action by protecting it from degradation.
DOI
Related Publication(s)
Review	Paper alert. Jones, 1998, Curr. Opin. Genet. Dev. 8(4): 377 [FBrf0104613]
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (18)
	arm^{S10.Scer\UAS.T:Hsap\MYC} dsh⁷⁵ Ecol\lacZ^Scer\UAS.cBa fz2^{ECD.GPI.Scer\UAS.T:Hsap\MYC} fz2^Scer\UAS.cCa pan^ΔN.Scer\UAS Scer\GAL4^69B Scer\GAL4^71B Scer\GAL4^Act5C.PP Scer\GAL4^en-e16E Scer\GAL4^h-1J3 Scer\GAL4^ptc-559.1 Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} Scer\GAL4^unspecified sgg^M11 w^+mC wg^l-12 wg^l-17
Constructs (7)
	P{GAL4-Act5C(FRT.CD2).P} P{GAL4-Act5C(-FRT).P} P{UAS-arm.S10} P{UAS-fz2.C} P{UAS-fz2(ECD)-GPI} P{UAS-lacZ.B} P{UAS-pan.dTCFΔN}
Genes (14)
	ac arm ct Dl Dll dsh Ecol\lacZ fz2 pan Scer\GAL4 sgg T:Hsap\MYC w wg
Insertions (5)
	P{en2.4-GAL4}e16E P{GawB}69B P{GawB}71B P{GawB}h^1J3 P{GawB}ptc^559.1