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Reference Report
| Reference | |||
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| Citation | Moore, M.S., DeZazzo, J., Luk, A.Y., Tully, T., Singh, C.M., Heberlein, U. (1998). Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93(6): 997--1007. (Export to RIS) | ||
| FlyBase ID | FBrf0102808 | ||
| Publication Type | Research paper | ||
| External Crossreferences | |||
| PubMed ID | 9635429 | ||
| PubMed Abstract | Upon exposure to ethanol, Drosophila display behaviors that are similar to ethanol intoxication in rodents and humans. Using an inebriometer to measure ethanol-induced loss of postural control, we identified cheapdate, a mutant with enhanced sensitivity to ethanol. Genetic and molecular analyses revealed that cheapdate is an allele of the memory mutant amnesiac. amnesiac has been postulated to encode a neuropeptide that activates the cAMP pathway. Consistent with this, we find that enhanced ethanol sensitivity of cheapdate can be reversed by treatment with agents that increase cAMP levels or PKA activity. Conversely, genetic or pharmacological reduction in PKA activity results in increased sensitivity to ethanol. Taken together, our results provide functional evidence for the involvement of the cAMP signal transduction pathway in the behavioral response to intoxicating levels of ethanol. | ||
| BIOSIS ID | 1313794 | ||
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Other Information
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| Language of Publication | English | ||
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Parent Publication
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| Publication Type | Journal | ||
| Abbreviation | Cell | ||
| Title | Cell | ||
| Editors | |||
| Publication Year | 1974- | ||
| ISBN/ISSN | 0092-8674 | ||
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Data from Reference
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| Alleles (16)
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| Constructs (1)
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| Genes (6)
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| Insertions (2)
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