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Citation
Moore, M.S., DeZazzo, J., Luk, A.Y., Tully, T., Singh, C.M., Heberlein, U. (1998). Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway.  Cell 93(6): 997--1007.
FlyBase ID
FBrf0102808
Publication Type
Research paper
Abstract

Upon exposure to ethanol, Drosophila display behaviors that are similar to ethanol intoxication in rodents and humans. Using an inebriometer to measure ethanol-induced loss of postural control, we identified cheapdate, a mutant with enhanced sensitivity to ethanol. Genetic and molecular analyses revealed that cheapdate is an allele of the memory mutant amnesiac. amnesiac has been postulated to encode a neuropeptide that activates the cAMP pathway. Consistent with this, we find that enhanced ethanol sensitivity of cheapdate can be reversed by treatment with agents that increase cAMP levels or PKA activity. Conversely, genetic or pharmacological reduction in PKA activity results in increased sensitivity to ethanol. Taken together, our results provide functional evidence for the involvement of the cAMP signal transduction pathway in the behavioral response to intoxicating levels of ethanol.

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PubMed Central ID
Related Publication(s)
Note

The fruit fly: a model organism to study the genetics of alcohol abuse and addiction?
Bellen, 1998, Cell 93(6): 909--912 [FBrf0102803]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Alleles (16)
    Genes (7)
    Human Disease Models (1)
    Insertions (2)
    Transgenic Constructs (1)