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Citation
Struhl, G., Adachi, A. (1998). Nuclear access and action of Notch in vivo.  Cell 93(4): 649--660.
FlyBase ID
FBrf0102819
Publication Type
Research paper
Abstract

The Drosophila Notch (N) gene encodes a conserved single-pass transmembrane receptor that transduces extracellular signals controlling cell fate. Here, we present evidence that the intracellular domain of Notch gains access to the nucleus in response to ligand, possibly through a mechanism involving proteolytic cleavage and release from the remainder of the protein. In addition, our results suggest that signal transduction by Notch depends on the ability of the intracellular domain, particularly the portion containing the CDC10 repeats, to reach the nucleus and to participate in the transcriptional activation of downstream target genes.

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PubMed Central ID
Related Publication(s)
Review

Paper alert.
Superti-Furga, 1998, Curr. Opin. Cell Biol. 10(4): 419 [FBrf0103457]

Paper alert.
Verrijzer, 1998, Curr. Opin. Cell Biol. 10(4): 420 [FBrf0103459]

Paper alert.
Verrijzer, 1998, Curr. Opin. Genet. Dev. 8(4): 374--375 [FBrf0104609]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Aberrations (2)
    Alleles (39)
    Balancers (1)
    Genes (15)
    Insertions (1)
    Experimental Tools (6)
    Transgenic Constructs (31)