Reference Report

Reference
Citation	Roch, F., Baonza, A., Martin-Blanco, E., Garcia-Bellido, A. (1998). Genetic interactions and cell behaviour in blistered mutants during proliferation and differentiation of the Drosophila wing. Development 125(10): 1823--1832. (Export to RIS)
FlyBase ID	FBrf0102828
Publication Type	Research paper
PubMed ID	9550715
PubMed Abstract	In this work, we analyse the blistered function in wing vein development by studying genetic mosaics of mutant cells, genetic interactions with other genes affecting vein development and blistered expression in several mutant backgrounds. blistered encodes for a nuclear protein homologous to the mammalian Serum Response Factor and is expressed in presumptive intervein cells of third larval instar and pupal wing discs. Clones of blistered mutant cells proliferate normally but tend to grow along veins and always differentiate as vein tissue. These observations indicate that vein-determined wing cells show a particular behaviour that is responsible for their allocation to vein regions. We observe strong genetic interactions between blistered, veinlet and genes of the Ras signaling cascade. During disc proliferation, blistered expression is under the control of the Ras signal transduction pathway, but its expression is independent of veinlet. During the pupal period, blistered and veinlet expression become interdependent and mutually exclusive. These results link the activity of the Ras pathway to the process of early determination of intervein cells, by the transcriptional control of the blistered nuclear factor.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (2)
	Df(2R)Px1 Dp(3;Y;1)M2
Alleles (34)
	Avic\GFP^Ubi-p63E.PD bs² bs⁰³²⁶⁷ Dl^M1 Ecol\lacZ^bs-03267 Egfr^E3 Egfr^f37 Egfr^II.Scer\UAS Egfr^t1 emc¹ emc^P5c f^36a f^+t13 M(2)58F^unspecified N^55e11 N^Ax-16 N^nd-3 phl¹¹ phl^{K497M.Scer\UAS} phl^K497M pwn¹ px⁷² Ras85D^{G13Q.Scer\UAS} rho⁹ rho^hs.PSt rho^ve-1 rl¹ rl¹⁰ rl^Sem Scer\GAL4^Bx-MS1096 vn¹ vn^ddd-3 vn^M2 w^+mC
Constructs (5)
	P{lacW-Δ12.M} P{UAS-Egfr.II} P{UAS-phl.KMRaf3.1} P{UAS-Ras85B.Act} P{Ubi-GFP.D}
Genes (18)
	Avic\GFP bs Dl Ecol\lacZ Egfr emc f M(2)58F N phl pwn px Ras85D rho rl Scer\GAL4 vn w
Insertions (3)
	P{FRT(w^hs)}101 P{GawB}Bx^MS1096 P{PZ}bs⁰³²⁶⁷