Reference Report

Reference
Citation	Johnston, L.A., Ostrow, B.D., Jasoni, C., Blochlinger, K. (1998). The homeobox gene cut interacts genetically with the homeotic genes proboscipedia and Antennapedia. Genetics 149(1): 131--142. (Export to RIS)
FlyBase ID	FBrf0102837
Publication Type	Research paper
PubMed ID	9584091
PubMed Abstract	The cut locus (ct) codes for a homeodomain protein (Cut) and controls the identity of a subset of cells in the peripheral nervous system in Drosophila. During a screen to identify ct-interacting genes, we observed that flies containing a hypomorphic ct mutation and a heterozygous deletion of the Antennapedia complex exhibit a transformation of mouthparts into leg and antennal structures similar to that seen in homozygous proboscipedia (pb) mutants. The same phenotype is produced with all heterozygous pb alleles tested and is fully penetrant in two different ct mutant backgrounds. We show that this phenotype is accompanied by pronounced changes in the expression patterns of both ct and pb in labial discs. Furthermore, a significant proportion of ct mutant flies that are heterozygous for certain Antennapedia (Antp) alleles have thoracic defects that mimic loss-of-function Antp phenotypes, and ectopic expression of Cut in antennal discs results in ectopic Antp expression and a dominant Antp-like phenotype. Our results implicate ct in the regulation of expression and/or function of two homeotic genes and document a new role of ct in the control of segmental identity.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (9)
	Df(3R)Antp2 Df(3R)LIN Df(3R)MAP2 Df(3R)MAP8 Df(3R)SCB-XL2 Df(3R)Scr In(3R)Antp^CB In(3R)Antp^R T(2;3)Antp¹⁷
Alleles (29)
	Antp² Antp³ Antp⁹ Antp¹¹ Antp¹⁶ Antp¹⁷ Antp²⁵ Antp^73b Antp^CB Antp^R Antp^Wu ct⁶ ct^C145 ct^hs.PB ct^K ct^L188 ct^Scer\UAS.cLa e¹ e^s N^{NM.hs.T:Hsap\MYC} p^p pb¹ pb⁵ pb¹⁴ pb²⁷ pb^SCB Scer\FLP1^hs.PG Scer\GAL4^dpp.blk1 st¹
Constructs (2)
	P{hsFLP} P{NM}
Genes (10)
	Antp ct e N p pb Scer\FLP1 Scer\GAL4 st T:Hsap\MYC