Reference Report

Reference
Citation	Ahmed, Y., Hayashi, S., Levine, A., Wieschaus, E. (1998). Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development. Cell 93(7): 1171--1182. (Export to RIS)
FlyBase ID	FBrf0102882
Publication Type	Research paper
PubMed ID	9657150
PubMed Abstract	We find that inactivation of a Drosophila homolog of the tumor suppressor APC (D-APC) causes retinal neuronal degeneration and pigment cell hypertrophy, a phenotype remarkably similar to that found in humans with germline APC mutations. Retinal degeneration in the D-APC mutant results from apoptotic cell death, which accompanies a defect in neuronal differentiation. Reduction in the Drosophila beta-catenin, Armadillo (Arm), rescues the differentiation defect and prevents apoptosis in the D-APC mutant, while Arm overexpression mimics D-APC inactivation. A mutation in dTCF, the DNA-binding protein required in Arm-mediated signal transduction, can eliminate the cell death without rescuing the differentiation defect in D-APC mutants. Uncoupling of these two Arm-induced processes suggests a novel role for the Arm/dTCF complex in the activation of apoptosis.
DOI
Related Publication(s)
Review	Paper Alert. Regulation of Armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development. Russ, 1998, Curr. Opin. Genet. Dev. 8(5): 505--506 [FBrf0104871] Paper alert. Russ, 1998, Curr. Opin. Cell Biol. 10(5): 558 [FBrf0105391]
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (1)
	Df(3R)3450
Alleles (17)
	Apc^Q8 Apc^S76 Apc^X1 arm⁴ arm⁸ arm^{S5.T:Hsap\MYC} arm^{S12.T:Hsap\MYC} arm^{S14.T:Hsap\MYC} arm^{S15.T:Hsap\MYC} arm^Scer\UAS.cSa arm^{Δ.Scer\FRT-.Scer\UAS.T:Ivir\HA1} BacA\p35^GMR.PH pan¹³ pan^ciD Scer\GAL4^elav-C155 Scer\GAL4^hs.2sev sgg^Scer\UAS.cSa
Constructs (9)
	P{arm.S5} P{arm.S12} P{arm.S14} P{arm.S15} P{GAL4-Hsp70.sev} P{GMRP35} P{UAS(-FRT)arm.Δ.flu} P{UAS-arm.S} P{UAS-sgg.S}
Genes (9)
	Apc arm BacA\p35 Nrt pan Scer\GAL4 sgg T:Hsap\MYC T:Ivir\HA1
Insertions (1)
	P{GawB}elav^C155