Reference Report

Reference
Citation	Civetta, A., Singh, R.S. (1998). Sex-related genes, directional sexual selection, and speciation. Mol. Biol. Evol. 15(7): 901--909. (Export to RIS)
FlyBase ID	FBrf0102904
Publication Type	Research paper
PubMed ID	9656489
PubMed Abstract	Reproductive isolation and speciation can result from the establishment of either premating or postmating barriers that restrict gene flow between populations. Recent studies of speciation have been dominated by a molecular approach to dissect the genetic basis of hybrid male sterility, a specific form of postmating reproductive isolation. However, relatively little attention has been paid to the evolution of genes involved in premating isolation and genes generally involved in other sex-related functions (e.g., mating behavior, fertilization, spermatogenesis, sex determination). We have assembled DNA sequences from 51 nuclear genes and classified them based on their functional characteristics. The proportion of nonsynonymous to synonymous nucleotide substitutions were compared between Drosophila melanogaster, Drosophila simulans, and Drosophila pseudoobscura, as well as between Caenorhabditis elegans and Caenorhabditis briggsae. We found a high ratio of nonsynonymous to synonymous substitutions for sex-related genes (i.e., genes involved in mating behavior, fertilization, spermatogenesis, or sex determination). The results suggest that directional sexual selection has shaped the evolution of sex-related genes and that these changes have more likely occurred during the early stages of speciation. It is possible that directional selection becomes relaxed after reproductive isolation has been completed between more distantly related species (e.g., D. melanogaster and D. pseudoobscura). However, a saturation in the number of nucleotide substitutions since the time of species separation may mask any sign of directional selection between more distantly related species.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Biol. Evol.
Title	Molecular Biology and Evolution
Publication Year	1983-
ISBN/ISSN	0737-4038 1537-1719
Data from Reference
Genes (82)
	Acp26Aa Acp26Ab ade3 Adh Amy-d Amy-p Anp Aprt bcd dpp Dpse\ade3 Dpse\Adh Dpse\Amy1 Dpse\Aprt Dpse\bcd Dpse\dpp Dpse\Est-5B Dpse\Est-5C Dpse\exu1 Dpse\exu2 Dpse\Gld Dpse\Gpdh Dpse\Hsp83 Dpse\janA Dpse\janB Dpse\l(2)gl Dpse\Mlc1 Dpse\ninaE Dpse\Rh2 Dpse\Rh3 Dpse\RpL32 Dpse\run Dpse\ry Dpse\Tl Dpse\Ubx Dpse\Uro Dsim\Acp26Aa Dsim\Acp26Ab Dsim\Adh Dsim\Amy-d Dsim\Amy-p Dsim\Anp Dsim\dpp Dsim\Est-6 Dsim\Hsp83 Dsim\Mlc1 Dsim\per Dsim\Pgd Dsim\Pgi Dsim\ref(2)P Dsim\sala Dsim\Sod Dsim\tra Dsim\v Dsim\w Est-6 exu Gld Gpdh Hsp83 janA janB l(2)gl Mlc1 ninaE per Pgd Pgi ref(2)P Rh2 Rh3 RpL32 run ry sala Sod Tl tra Ubx Uro v w