Reference Report

Reference
Citation	Neufeld, T.P., de la Cruz, A.F., Johnston, L.A., Edgar, B.A. (1998). Coordination of growth and cell division in the Drosophila wing. Cell 93(7): 1183--1193. (Export to RIS)
FlyBase ID	FBrf0102989
Publication Type	Research paper
PubMed ID	9657151
PubMed Abstract	In most tissues, cell division is coordinated with increases in mass (i.e., growth). To understand this coordination, we altered rates of division in cell clones or compartments of the Drosophila wing and measured the effects on growth. Constitutive overproduction of the transcriptional regulator dE2F increased expression of the S- and M-phase initiators Cyclin E and String (Cdc25), thereby accelerating cell proliferation. Loss of dE2F or overproduction of its corepressor, RBF, retarded cell proliferation. These manipulations altered cell numbers over a 4- to 5-fold range but had little effect on clone or compartment sizes. Instead, changes in cell division rates were offset by changes in cell size. We infer that dE2F and RBF function specifically in cell cycle control, and that cell cycle acceleration is insufficient to stimulate growth. Variations in dE2F activity could be used to coordinate cell division with growth.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (16)
	Avic\GFP^{S65T.Scer\UAS.T:SV40\nls2} Avic\GFP^{S65T.Scer\UAS} BacA\p35^Scer\UAS.cHa CycE^Scer\UAS.cLa Dp^Scer\UAS.cDa E2f^rM729 E2f^Scer\UAS.cNa Rbf^Scer\UAS.cDa RpS3^Plac92 Scer\GAL4^Act5C.PP Scer\GAL4^en-e16E Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} stg² stg⁶ stg^Scer\UAS.cNa w^+mC
Constructs (10)
	P{GAL4-Act5C(FRT.CD2).P} P{GAL4-Act5C(-FRT).P} P{UAS-CycE.L} P{UAS-Dp.D} P{UAS-E2f.N} P{UAS-GFP.S65T} P{UAS-GFP^S65T.nls} P{UAS-p35.H} P{UAS-Rbf.D} P{UAS-stg.N}
Genes (11)
	Avic\GFP BacA\p35 CycE Dp E2f Rbf RpS3 Scer\GAL4 stg T:SV40\nls2 w
Insertions (2)
	P{en2.4-GAL4}e16E P{PZ}E2f^rM729