Reference Report

Reference
Citation	Boutros, M., Paricio, N., Strutt, D.I., Mlodzik, M. (1998). Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94(1): 109--118. (Export to RIS)
FlyBase ID	FBrf0103240
Publication Type	Research paper
External Crossreferences
PubMed ID	9674432
PubMed Abstract	Frizzled family proteins have been described as receptors of Wnt signaling molecules. In Drosophila, the two known Frizzled proteins are associated with distinct developmental processes. Genesis of epithelial planar polarity requires Frizzled, whereas Dfz2 affects morphogenesis by wingless-mediated signaling. Dishevelled is required in both signaling pathways. Here, we use genetic and overexpression assays to show that Dishevelled activates JNK cascades. Rescue analysis reveals different protein domain requirements in Dishevelled for the two pathways; the C-terminal DEP domain is essential to rescue planar polarity defects and induce JNK signaling. Furthermore, the planar polarity-specific dsh1 allele is mutated in the DEP domain. Our results indicate that different Wnt/Fz signals activate distinct intracellular pathways, and Dishevelled discriminates among them by distinct domain interactions.
BIOSIS ID	1360851
Zoological Record ID
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Editors
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (2)
	Df(3L)Ar14-8 Df(3L)pbl-X1
Alleles (27)
	arm² arm⁸ bsk² bsk^Scer\UAS.cBa Cdc42³ dsh^1.hs.sev dsh¹ dsh³ dsh^hs.sev.B dsh^ΔC.hs.sev dsh^ΔDIX.hs.sev dsh^ΔPDZ.hs.sev fz^hs.sev hep^r75 hep^Scer\UAS.cBa Jra¹ Jra^hs.sev Jra^IA109 pan¹³ pan^ER1 Ras85D^e2F Rho1^k07903 Rho1^V14.sev rl¹⁰ Scer\GAL4^unspecified w^+mC wg^l-17
Constructs (11)
	P{NM} P{sE-Dsh.B} P{sE-Dsh¹.B} P{sE-DshΔC.B} P{sE-DshΔDIX.B} P{sE-DshΔPDZ.B} P{sE-jun^wt} P{sE-Rho1.V14} P{sev-fz.T} P{UAS-bsk.B} P{UAS-hep.B}
Genes (17)
	arm bsk Cdc42 dsh fz fz2 hep Jra pan Rac1 Rac2 Ras85D Rho1 rl Scer\GAL4 w wg