FB2025_01 , released February 20, 2025
Reference Report
Open Close
Reference
Citation
Lu, J., Andrews, J., Pauli, D., Oliver, B. (1998). Drosophila OVO zinc-finger protein regulates ovo and ovarian tumor target promoters.  Dev. Genes Evol. 208(4): 213--222.
FlyBase ID
FBrf0103322
Publication Type
Research paper
Abstract
The ovo+ and ovarian tumor+ genes function in the germline sex determination pathway in Drosophila, but the hierarchical relationship between them is unknown. We found that increased ovo+ copy number resulted in increased ovarian tumor expression in the female germline and increased ovo expression in the male germline. The ovo locus encodes C2H2 zinc-finger proteins. Bacterially expressed OVO zinc-finger domain bound to multiple sites at or near the ovo and ovarian tumor promoters strongly suggesting that OVO is directly autoregulatory and that ovarian tumor is a direct downstream target of ovo in the germline sex determination hierarchy. Both positive and negative regulation by OVO proteins appears likely, depending on promoter context and on the sex of the fly. Our observation that two strong OVO-binding sites are at the initiator of the TATA-less ovo-B and ovarian tumor promoters raises the possibility that OVO proteins influence the nucleation of transcriptional pre-initiation complexes.
PubMed ID
PubMed Central ID
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Genes Evol.
    Title
    Development genes and evolution
    Publication Year
    1996-
    ISBN/ISSN
    0949-944X
    Data From Reference
    Aberrations (2)
    Alleles (12)
    Genes (4)
    Sequence Features (6)
    Transgenic Constructs (5)