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Reference
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| Citation |
Carrera, P., Abrell, S., Kerber, B., Walldorf, U., Preiss, A., Hoch, M., Jackle, H. (1998). A modifier screen in the eye reveals control genes for Kruppel activity in the Drosophila embryo. Proc. Natl. Acad. Sci. USA 95(18): 10779--10784. |
| FlyBase ID |
FBrf0104417 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
9724781 |
| PubMed Abstract |
Irregular facets (If) is a dominant mutation of Drosophila that results in small eyes with fused ommatidia. Previous results
showed that the gene Krüppel (Kr), which is best known for its early segmentation function, is expressed ectopically in If
mutant eye discs. However, it was not known whether ectopic Kr activity is either the cause or the result of the If mutation.
Here, we show that If is a gain-of-function allele of Kr. We then used the If mutation in a genetic screen to identify dominant
enhancers and suppressors of Kr activity on the third chromosome. Of 30 identified Kr-interacting loci, two were cloned, and
we examined whether they also represent components of a natural Kr-dependent developmental pathway of the embryo. We show
that the two genes, eyelid (eld) and extramacrochaetae (emc), which encode a Bright family-type DNA binding protein and a
helix-loop-helix factor, respectively, are necessary to achieve the singling-out of a unique Kr-expressing cell during the
development of the Malpighian tubules, the excretory organs of the fly. The results indicate that the Kr gain-of-function
mutation If provides a tool to identify genes that are active during eye development and that a number of them function also
in the control of Kr-dependent developmental processes.
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| Biosis |
1449396 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Proc. Natl. Acad. Sci. USA |
| Title |
Proceedings of the National Academy of Sciences of the United States of America |
| Authors |
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| Volume range |
1- |
| Year range |
1915- |
| Page range |
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| Publisher |
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| Place of publication |
Washington, DC |
| Language of publication |
English |
| ISBN/ISSN |
0027-8424 |
| CODEN |
PNASA6 |
Data from Reference
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Aberrations (70)
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Alleles (28)
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Constructs (3)
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Genes (20)
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Insertions (3)
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