Home
Reference Report
| Reference | |||
|---|---|---|---|
| Citation | Carrera, P., Abrell, S., Kerber, B., Walldorf, U., Preiss, A., Hoch, M., Jackle, H. (1998). A modifier screen in the eye reveals control genes for Kruppel activity in the Drosophila embryo. Proc. Natl. Acad. Sci. U.S.A. 95(18): 10779--10784. (Export to RIS) | ||
| FlyBase ID | FBrf0104417 | ||
| Publication Type | Research paper | ||
| External Crossreferences | |||
| PubMed ID | 9724781 | ||
| PubMed Abstract | Irregular facets (If) is a dominant mutation of Drosophila that results in small eyes with fused ommatidia. Previous results showed that the gene Krüppel (Kr), which is best known for its early segmentation function, is expressed ectopically in If mutant eye discs. However, it was not known whether ectopic Kr activity is either the cause or the result of the If mutation. Here, we show that If is a gain-of-function allele of Kr. We then used the If mutation in a genetic screen to identify dominant enhancers and suppressors of Kr activity on the third chromosome. Of 30 identified Kr-interacting loci, two were cloned, and we examined whether they also represent components of a natural Kr-dependent developmental pathway of the embryo. We show that the two genes, eyelid (eld) and extramacrochaetae (emc), which encode a Bright family-type DNA binding protein and a helix-loop-helix factor, respectively, are necessary to achieve the singling-out of a unique Kr-expressing cell during the development of the Malpighian tubules, the excretory organs of the fly. The results indicate that the Kr gain-of-function mutation If provides a tool to identify genes that are active during eye development and that a number of them function also in the control of Kr-dependent developmental processes. | ||
| BIOSIS ID | 1449396 | ||
| Zoological Record ID | |||
Recent Updates
|
|||
| Description |
What does this section display?
This section contains items that were added to this record for each release.
It currently only tracks new links between this FlyBase report and other
FlyBase data classes (e.g. genes, references, stocks) or controlled
vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
|
||
| Update Feed |
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your
feed reader.
|
||
| FB2012_01 | |||
| FB2011_10 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
|
Associated Information
|
|||
| Comments | |||
| Text of Personal Communication | |||
| Associated Files | |||
|
Other Information
|
|||
| Secondary IDs | |||
| Language of Publication | English | ||
| Additional Languages of Abstract | |||
| ISBN | |||
|
Parent Publication
|
|||
| Publication Type | Journal | ||
| Abbreviation | Proc. Natl. Acad. Sci. U.S.A. | ||
| Title | Proceedings of the National Academy of Sciences of the United States of America | ||
| Editors | |||
| Publication Year | 1915- | ||
| ISBN/ISSN | 0027-8424 | ||
|
Data from Reference
|
|||
| Aberrations (70)
|
|||
|
|||
| Alleles (28)
|
|||
| Constructs (3)
|
|||
| Genes (20)
|
|||
| Insertions (3)
|
|||