Reference Report

Reference
Citation	Hoang, B., Chiba, A. (1998). Genetic analysis on the role of integrin during axon guidance in Drosophila. J. Neurosci. 18(19): 7847--7855. (Export to RIS)
FlyBase ID	FBrf0104450
Publication Type	Research paper
PubMed ID	9742153
PubMed Abstract	Heterodimeric cell surface receptor integrin is widely expressed in the nervous system, but its specific role during axon development has not been directly tested in vivo. We show that the Drosophila nervous system expresses low levels of positron-specific (PS) integrin subunits alphaPS1, alphaPS2, and betaPS during embryonic axogenesis. Furthermore, certain subsets of neurons express higher levels of integrin mRNAs than do the rest. Null mutations in either the alphaPS1 or alphaPS2 subunit gene cause widespread axon pathfinding errors that can be rescued by supplying the wild-type integrin subunit to the mutant nervous system. In contrast, misexpressing either the alphaPS1 or alphaPS2 integrin subunit in all neurons leads to no obvious axon pathfinding errors. We propose that integrin does not itself serve as either a "clutch" constituting molecule or a specific growth cone "receptor," as proposed previously, but rather as part of a molecular network that cooperatively guarantees accurate axon guidance.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Neurosci.
Title	Journal of Neuroscience
Publication Year	1981-
ISBN/ISSN	0270-6474 1529-2401
Data from Reference
Alleles (9)
	if^B2 if^C.Scer\UAS if^k27e mew⁴⁹⁸ mew^M6 mew^Scer\UAS.cWa mys¹⁰ Scer\GAL4^elav.PLu Scer\GAL4^elav-C155
Constructs (3)
	P{GAL4-elav.L} P{UAS-if.C} P{UAS-mew.W}
Genes (4)
	if mew mys Scer\GAL4
Insertions (1)
	P{GawB}elav^C155