Reference Report

Reference
Citation	Morris, J.R., Chen, J., Geyer, P.K., Wu, C. (1998). Two modes of transvection: enhancer action in trans and bypass of a chromatin insulator in cis. Proc. Natl. Acad. Sci. U.S.A. 95(18): 10740--10745. (Export to RIS)
FlyBase ID	FBrf0104488
Publication Type	Research paper
PubMed ID	9724774
PubMed Abstract	Ed Lewis introduced the term "transvection" in 1954 to describe mechanisms that can cause the expression of a gene to be sensitive to the proximity of its homologue. Transvection since has been reported at an increasing number of loci in Drosophila, where homologous chromosomes are paired in somatic tissues, as well as at loci in other organisms. At the Drosophila yellow gene, transvection can explain intragenic complementation involving the yellow2 allele (y2). Here, transvection was proposed to occur by enhancers of one allele acting in trans on the promoter of a paired homologue. In this report, we describe two yellow alleles that strengthen this model and reveal an unexpected, second mechanism for transvection. Data suggest that, in addition to enhancer action in trans, transvection can occur by enhancer bypass of a chromatin insulator in cis. We propose that bypass results from the topology of paired genes. Finally, transvection at yellow can occur in genotypes not involving y2, implying that it is a feature of yellow itself and not an attribute of one particular allele.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Alleles (10)
	w^+mC y^1#8 y² y^3c3 y^82f29 y^+t5'BglΔ961 y^+t7.7 y^+tSalΔ534 y^+tSalΔ961 y^unspecified
Constructs (3)
	P{5'BglΔ961} P{SalΔ534} P{SalΔ961}
Genes (2)
	w y
Insertions (1)
	gypsy{}y²