Reference Report

Reference
Citation	Zeng, C., Justice, N.J., Abdelilah, S., Chan, Y.M., Jan, L.Y., Jan, Y.N. (1998). The Drosophila LIM-only gene, dLMO, is mutated in beadex alleles and might represent an evolutionarily conserved function in appendage development. Proc. Natl. Acad. Sci. U.S.A. 95(18): 10637--10642. (Export to RIS)
FlyBase ID	FBrf0104534
Publication Type	Research paper
PubMed ID	9724756
PubMed Abstract	The process of wing patterning involves precise molecular mechanisms to establish an organizing center at the dorsal-ventral boundary, which functions to direct the development of the Drosophila wing. We report that misexpression of dLMO, a Drosophila LIM-only protein, in specific patterns in the developing wing imaginal disc, disrupts the dorsal-ventral (D-V) boundary and causes errors in wing patterning. When dLMO is misexpressed along the anterior-posterior boundary, extra wing outgrowth occurs, similar to the phenotype seen when mutant clones lacking Apterous, a LIM homeodomain protein known to be essential for normal D-V patterning of the wing, are made in the wing disc. When dLMO is misexpressed along the D-V boundary in third instar larvae, loss of the wing margin is observed. This phenotype is very similar to the phenotype of Beadex, a long-studied dominant mutation that we show disrupts the dLMO transcript in the 3' untranslated region. dLMO normally is expressed in the wing pouch of the third instar wing imaginal disc during patterning. A mammalian homolog of dLMO is expressed in the developing limb bud of the mouse. This indicates that LMO proteins might function in an evolutionarily conserved mechanism involved in patterning the appendages.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Alleles (12)
	Bx¹ Bx³ Bx^EP1306 Bx^EP1383 Bx^EP1394 Bx^J Bx^Scer\UAS.cZa Bx^{Scer\UAS.T:Hsap\MYC} Ecol\lacZ^wg-en11 Scer\GAL4^ptc-559.1 Scer\GAL4^Ser.PGF w^+mC
Constructs (3)
	P{Ser-GAL4.GF} P{UAS-Bx.T:Myc} P{UAS-Bx.Z}
Genes (6)
	Bx ct Ecol\lacZ Scer\GAL4 T:Hsap\MYC w
Insertions (5)
	P{en1}wg^en11 P{EP}Bx^EP1306 P{EP}Bx^EP1383 P{EP}Bx^EP1394 P{GawB}ptc^559.1