Reference Report

Reference
Citation	Bernardoni, R., Miller, A.A., Giangrande, A. (1998). Glial differentiation does not require a neural ground state. Development 125(16): 3189--3200. (Export to RIS)
FlyBase ID	FBrf0104717
Publication Type	Research paper
PubMed ID	9671591
PubMed Abstract	Glial cells differentiate from the neuroepithelium. In flies, gliogenesis depends on the expression of glial cell deficient/glial cell missing (glide/gcm). The phenotype of glide/gcm loss- and gain-of-function mutations suggested that gliogenesis occurs in cells that, by default, would differentiate into neurons. Here we show that glide/gcm is able to induce cells even from a distinct germ layer, the mesoderm, to activate the glial developmental program, which demonstrates that gliogenesis does not require a ground neural state. These findings challenge the common view on the establishment of cell diversity in the nervous system. Strikingly, ectopic glide/gcm overrides positional information by repressing the endogenous developmental program. These findings also indicate that glial differentiation tightly depends on glide/gcm transcriptional regulation. It is likely that glide/gcm homologs act similarly during vertebrate gliogenesis.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (10)
	Ecol\lacZ^AA142 Ecol\lacZ^Gli-AE2 Ecol\lacZ^loco-rC56 Ecol\lacZ^Scer\UAS.cBa gcm^Scer\UAS.cBa Scer\GAL4^elav.PLu Scer\GAL4^how-24B Scer\GAL4^pnr-MD237 Scer\GAL4^sca-4512 Scer\GAL4^twi.PB
Constructs (4)
	P{GAL4-elav.L} P{GAL4-twi.B} P{UAS-gcm.B} P{UAS-lacZ.B}
Genes (6)
	Ecol\lacZ gcm Mef2 Mhc repo Scer\GAL4
Insertions (6)
	P{GAL4}sca⁴⁵¹² P{GawB}how^24B P{GawB}pnr^MD237 P{lacW}Gli^AE2 P{lacZ-un1}loco^rC56 P{lwB}AA142