Reference Report

Reference
Citation	Chaboissier, M.C., Bucheton, A., Finnegan, D.J. (1998). Copy number control of a transposable element, the I factor, a LINE-like element in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 95(20): 11781--11785. (Export to RIS)
FlyBase ID	FBrf0104736
Publication Type	Research paper
PubMed ID	9751742
PubMed Abstract	The I factor is a LINE-like transposable element in Drosophila. Most strains of Drosophila melanogaster, inducer strains, contain 10-15 copies of the I factor per haploid genome located in the euchromatic regions of the chromosome arms. These are not present in a few strains known as reactive strains. I factors transpose at low frequency in inducer strains but at high frequency in the female progeny of crosses between reactive and inducer flies. We have found that the activity of the I factor promoter is sensitive to the number of copies of the first 186 nucleotides of the I factor sequence, which constitutes the 5'-untranslated region. The activity of the I factor decreases as the copy number of this sequence increases.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Alleles (9)
	Ecol\CAT^{I-element.2x186} Ecol\CAT^{I-element.3x186} Ecol\CAT^{I-element.Δ2x186} Ecol\CAT^{I-element.Δ3x186} I-element\gag^IR3 I-element\RTase^IR3 w^+mW.hs y^+t7.7 y^+t*
Constructs (7)
	I{954Y} P{I.954Y} P{I-element-CAT.2x186} P{I-element-CAT.3x186} P{I-element-CAT.Δ2x186} P{I-element-CAT.Δ3x186} pP{I{954Y}}
Genes (3)
	Ecol\CAT w y
Insertions (2)
	I{954Y}21.1 I{954Y}57.3
Natural transposons (1)
	I-element