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Reference Report
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| Citation | Godt, D., Tepass, U. (1998). Drosophila oocyte localization is mediated by differential cadherin-based adhesion. Nature 395(6700): 387--391. (Export to RIS) | ||
| FlyBase ID | FBrf0104749 | ||
| Publication Type | Research paper | ||
| PubMed ID | 9759729 | ||
| PubMed Abstract | In a Drosophila follicle the oocyte always occupies a posterior position among a group of sixteen germline cells. Although the importance of this cell arrangement for the subsequent formation of the anterior-posterior axis of the embryo is well documented, the molecular mechanism responsible for the posterior localization of the oocyte was unknown. Here we show that the homophilic adhesion molecule DE-cadherin mediates oocyte positioning. During follicle biogenesis, DE-cadherin is expressed in germline (including oocyte) and surrounding follicle cells, with the highest concentration of DE-cadherin being found at the interface between oocyte and posterior follicle cells. Mosaic analysis shows that DE-cadherin is required in both germline and follicle cells for correct oocyte localization, indicating that germline-soma interactions may be involved in this process. By analysing the behaviour of the oocyte in follicles with a chimaeric follicular epithelium, we find that the position of the oocyte is determined by the position of DE-cadherin-expressing follicle cells, to which the oocyte attaches itself selectively. Among the DE-cadherin positive follicle cells, the oocyte preferentially contacts those cells that express higher levels of DE-cadherin. On the basis of these data, we propose that in wild-type follicles the oocyte competes successfully with its sister germline cells for contact to the posterior follicle cells, a sorting process driven by different concentrations of DE-cadherin. This is, to our knowledge, the first in vivo example of a cell-sorting process that depends on differential adhesion mediated by a cadherin. | ||
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| Related Publication(s) | |||
| Review | Paper alert. Pfaff, 1998, Curr. Opin. Cell Biol. 10(6): 678--679 [FBrf0107095] |
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| Language of Publication | English | ||
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Parent Publication
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| Publication Type | Journal | ||
| Abbreviation | Nature | ||
| Title | Nature | ||
| Publication Year | 1869- | ||
| ISBN/ISSN | 0028-0836 | ||
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Data from Reference
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| Aberrations (1)
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| Alleles (5)
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| Genes (8)
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| Insertions (2)
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