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Cavallo, R.A., Cox, R.T., Moline, M.M., Roose, J., Polevoy, G.A., Clevers, H., Peifer, M., Bejsovec, A. (1998). Drosophila Tcf and Groucho interact to repress Wingless signalling activity.  Nature 395(6702): 604--608.
FlyBase ID
FBrf0104944
Publication Type
Research paper
Abstract

Wingless/Wnt signalling directs cell-fate choices during embryonic development. Inappropriate reactivation of the pathway causes cancer. In Drosophila, signal transduction from Wingless stabilizes cytosolic Armadillo, which then forms a bipartite transcription factor with the HMG-box protein Drosophila Tcf (dTcf) and activates expression of Wingless-responsive genes. Here we report that in the absence of Armadillo, dTcf acts as a transcriptional repressor of Wingless-responsive genes, and we show that Groucho acts as a corepressor in this process. Reduction of dTcf activity partially suppresses wingless and armadillo mutant phenotypes, leading to derepression of Wingless-responsive genes. Furthermore, overexpression of wild-type dTcf enhances the phenotype of a weak wingless allele. Finally, mutations in the Drosophila groucho gene also suppress wingless and armadillo mutant phenotypes as Groucho physically interacts with dTcf and is required for its full repressor activity.

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PubMed Central ID
Related Publication(s)
Review

Paper alert.
Verrijzer, 1998, Curr. Opin. Genet. Dev. 8(6): 605 [FBrf0106069]

Paper alert.
Jones, 1998, Curr. Opin. Genet. Dev. 8(6): 607 [FBrf0106070]

Paper alert.
Miska, 1998, Curr. Opin. Genet. Dev. 8(6): 608 [FBrf0106072]

Paper alert.
Verrijzer, 1998, Curr. Opin. Cell Biol. 10(6): 676 [FBrf0107416]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nature
    Title
    Nature
    Publication Year
    1869-
    ISBN/ISSN
    0028-0836
    Data From Reference
    Aberrations (4)
    Alleles (14)
    Gene Groups (2)
    Genes (7)
    Transgenic Constructs (2)