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Citation
Bergmann, A., Agapite, J., McCall, K., Steller, H. (1998). The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling.  Cell 95(3): 331--341.
FlyBase ID
FBrf0105197
Publication Type
Research paper
Abstract

Extracellular growth factors are required for the survival of most animal cells. They often signal through the activation of the Ras pathway. However, the molecular mechanisms by which Ras signaling inhibits the intrinsic cell death machinery are not well understood. Here, we present evidence that in Drosophila, activation of the Ras pathway specifically inhibits the proapoptotic activity of the gene head involution defective (hid). By using transgenic animals and cultured cells, we show that MAPK phosphorylation sites in Hid are critical for this response. These findings define a novel mechanism by which growth factor signaling directly inactivates a critical component of the intrinsic cell death machinery. These studies provide further insights into the function of ras as an oncogene.

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Note

Dying like flies.
Meier and Evan, 1998, Cell 95(3): 295--298 [FBrf0105421]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference