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Reference
Citation
Therrien, M., Wong, A.M., Rubin, G.M. (1998). CNK, a RAF-binding multidomain protein required for RAS signaling.  Cell 95(3): 343--353.
FlyBase ID
FBrf0105423
Publication Type
Research paper
Abstract

Kinase suppressor of ras (ksr) is required for efficient signal transmission within the RAS/MAPK cascade. A screen for mutations that modify a ksr-dependent phenotype identified a novel gene, connector enhancer of ksr (cnk), that functions upstream or in parallel to RAF in the RAS pathway. cnk encodes a protein containing several protein-protein interaction domains, suggesting that it brings different signaling molecules together. CNK is required in multiple receptor tyrosine kinase pathways where it appears to be a tyrosine phosphorylation target. Finally, CNK physically interacts with RAF and appears to localize to cell-cell contact regions. Together, these findings suggest that CNK is a novel component of a RAS-dependent signaling pathway that regulates RAF function and/or targets RAF to a specific subcellular compartment upon RAS activation.

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PubMed Central ID
Related Publication(s)
Review

Paper alert.
Ridley, 1999, Curr. Opin. Genet. Dev. 9(1): 1 [FBrf0107161]

Paper alert.
Superti-Furga, 1999, Curr. Opin. Cell Biol. 11(1): 3 [FBrf0108020]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Alleles (16)
    Gene Groups (2)
    Genes (12)
    Physical Interactions (3)
    Cell Lines (1)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (2)