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Citation
Akiyama-Oda, Y., Hosoya, T., Hotta, Y. (1998). Alteration of cell fate by ectopic expression of Drosophila glial cells missing in non-neural cells.  Dev. Genes Evol. 208(10): 578--585.
FlyBase ID
FBrf0105765
Publication Type
Research paper
Abstract

The glial cells missing (gcm) gene encodes an essential transcription factor that converts neuronal precursor cells to glial fate in the Drosophila nervous system. In this study, we tested effects of gcm ectopic expression on fate of non-neural cells. When gcm expression was continuously induced in epidermal cells from around stage 9, these cells started to exhibit mesenchymal cell morphology at stage 13, which was preceded by the onset of expression of Repo, a glial marker. The morphological change was coincident with loss of expression of an epidermal cell-adhesion molecule. In addition to the epidermis, fate of mesodermal cells was also affected by gcm ectopic expression. These findings suggest that gcm can convert gene expression and cell morphology even outside the neuroectoderm.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Genes Evol.
    Title
    Development genes and evolution
    Publication Year
    1996-
    ISBN/ISSN
    0949-944X
    Data From Reference
    Alleles (6)
    Genes (9)
    Insertions (3)
    Transgenic Constructs (3)