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Citation
Bentrop, J. (1998). Rhodopsin mutations as the cause of retinal degeneration. classification Of degeneration phenotypes in the model system Drosophila melanogaster.  Acta Anat. 162(2-3): 85--94.
FlyBase ID
FBrf0105775
Publication Type
Review
Abstract

Insight into the molecular basis of inherited photoreceptor cell degeneration has been rapidly evolving during the last decade. The Drosophila Rh1 rhodopsin gene was the first gene shown to cause retinal degeneration when mutated. Many more degeneration-causing mutations in genes encoding rhodopsin and other photoreceptor proteins have been isolated since then in both, Drosophila and humans. To date some 70 mutations of the Drosophila Rh1 gene have been isolated, most of them have been characterized at the molecular level, and more than 60% of them cause retinal degeneration. This review lists the known Rh1 mutations that cause retinal degeneration up to April 1998, gives an overview on the ultrastructural and biochemical correlates of photoreceptor cell degeneration, and suggests a system for the classification of degeneration-causing Rh1 mutations.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Acta Anat.
    Title
    Acta Anatomica
    Publication Year
    1945-
    ISBN/ISSN
    0001-5180
    Data From Reference