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Reference
Citation	Chen, C.K., Kuhnlein, R.P., Eulenberg, K.G., Vincent, S., Affolter, M., Schuh, R. (1998). The transcription factors KNIRPS and KNIRPS RELATED control cell migration and branch morphogenesis during Drosophila tracheal development. Development 125(24): 4959--4968.
FlyBase ID	FBrf0105788
Type of publication	Research paper
Offprint Available	Yes
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PubMed ID	9811580
PubMed Abstract	Cell migration during embryonic tracheal system development in Drosophila requires DPP and EGF signaling to generate the archetypal branching pattern. We show that two genes encoding the transcription factors KNIRPS and KNIRPS RELATED possess multiple and redundant functions during tracheal development. knirps/knirps related activity is necessary to mediate DPP signaling which is required for tracheal cell migration and formation of the dorsal and ventral branches. Ectopic knirps or knirps related expression in lateral tracheal cells respecifies their anteroposterior to a dorsoventral migration behavior, similar to that observed in the case of ectopic DPP expression. In dorsal tracheal cells knirps/knirps related activity represses the transcription factor SPALT; this repression is essential for secondary and terminal branch formation. However, in cells of the dorsal trunk, spalt expression is required for normal anteroposterior cell migration and morphogenesis. spalt expression is maintained by the EGF receptor pathway and, hence, some of the opposing activities of the EGF and DPP signaling pathways are mediated by spalt and knirps/knirps related. Furthermore, we provide evidence that the border between cells acquiring dorsal branch and dorsal trunk identity is established by the direct interaction of KNIRPS with a spalt cis-regulatory element.
Biosis	1999.98182
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Language of publication	English
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Abbreviation	Development
Title	Development
Authors
Volume range	99-
Year range	1987-
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Place of publication	Cambridge
Language of publication	English
ISBN/ISSN	0950-1991
CODEN	DEVPED
Data from Reference
Aberrations (1)
	Df(3L)ri-XT1
Alleles (21)
	Avic\GFP^{Scer\UAS.T:Ecol\lacZ,T:SV40\nls2} Ecol\lacZ^kni.PW Ecol\lacZ^salm.TSE1000 Ecol\lacZ^salm.TSE157 Ecol\lacZ^salm.TSE201 Ecol\lacZ^salm.TSE230 Ecol\lacZ^salm.TSE410 Ecol\lacZ^salm.TSE590 Egfr^f4 Egfr^f7 Scer\GAL4^btl.PS dpp^Scer\UAS.cRa kni⁸ kni^Scer\UAS.cCa kni^tRa knrl^Scer\UAS.cLa rho^7M43 salm³ salm^Scer\UAS.cKa spi¹ w^+mC
Constructs (14)
	H{UAS-dpp.R} P{GAL4-btl.S} P{UAS-GFP::lacZ.nls} P{UAS-kni.C} P{UAS-knrl.L} P{UAS-salm.K} P{kni-lacZ.W} P{kniSH} P{salm-lacZ.TSE1000} P{salm-lacZ.TSE157} P{salm-lacZ.TSE201} P{salm-lacZ.TSE230} P{salm-lacZ.TSE410} P{salm-lacZ.TSE590}
Genes (16)
	Avic\GFP Ecol\lacZ Egfr Scer\GAL4 T:Ecol\lacZ T:SV40\nls2 bnl btl dpp kni knrl rho salm spi tkv w