Reference Report

Reference
Citation	Chu, H., Parras, C., White, K., Jimenez, F. (1998). Formation and specification of ventral neuroblasts is controlled by vnd in Drosophila neurogenesis. Genes Dev. 12(22): 3613--3624. (Export to RIS)
FlyBase ID	FBrf0105792
Publication Type	Research paper
PubMed ID	9832512
PubMed Abstract	During Drosophila neural development, neuroblasts delaminate from the neuroectoderm of each hemisegment in a stereotypic orthogonal array of five rows and three columns (ventral, intermediate, and dorsal). Prevailing evidence indicates that the individual neuroblast fate is determined by the domain-specific expression of genes along the dorsoventral and anteroposterior axis. Here, we analyze the role of Vnd, a NK-2 homeodomain protein, expressed initially in the ventral neuroectoderm adjacent to the ventral midline, in the dorsoventral patterning of the neuroectoderm and the neuroblasts. We show that in vnd null mutants most ventral neuroblasts do not form and the few that form do not develop ventral fates, but instead develop intermediate-like fates. Furthermore, we demonstrate that Vnd influences the gene expression patterns in the ventral proneural clusters and neuroectoderm, and that its action in neuroblast formation includes, but is not exclusive to the activation of proneural AS-C genes. Through the use of GAL4/UAS gene-expression system we show that ectopic Vnd expression can promote ventral-like fates in intermediate and dorsal neuroblasts and can suppress certain normal characteristics of the intermediate and dorsal neuroectoderm. Our results are discussed in the context of the current evidence in dorsoventral patterning in the Drosophila neuroectoderm.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Aberrations (3)
	Df(1)sc19 Df(1)vnd^D38 In(1)y^3PLsc^8R
Alleles (14)
	ac^Scer\UAS.cPa Appl^d Ecol\lacZ^Dr-rH96 Ecol\lacZ^hkb-5953 Ecol\lacZ^svp-3 l(1)sc^Scer\UAS.cPa sc^Scer\UAS.cPa Scer\GAL4^Kr.PM Scer\GAL4^rho.PL Scer\GAL4^sca-537.4 vnd⁵ vnd^D38 vnd^Scer\UAS.cCa w^+mC
Constructs (6)
	P{GAL4-Kr.C} P{GAL4-ve.L} P{UAS-ac} P{UAS-l'sc} P{UAS-sc.P} P{UAS-vnd.C}
Genes (19)
	ac Appl Ecol\lacZ elav eve Fas2 ftz gsb hb hkb l(1)1Bg l(1)sc lbe odd sc Scer\GAL4 vnd w zfh1
Insertions (5)
	P{GawB}sca^537.4 P{HZ}svp³ P{lacZ-un1}Dr^rH96 P{lacZ-un1}rF124 P{lacZ-un4}hkb⁵⁹⁵³