Reference Report

Reference
Citation	Fostier, M., Evans, D.A., Artavanis-Tsakonas, S., Baron, M. (1998). Genetic characterization of the Drosophila melanogaster suppressor of deltex gene: a regulator of Notch signaling. Genetics 150(4): 1477--1485. (Export to RIS)
FlyBase ID	FBrf0105825
Publication Type	Research paper
PubMed ID	9832525
PubMed Abstract	The Notch receptor signaling pathway regulates cell differentiation during the development of multicellular organisms. A number of genes are known to be components of the pathway or regulators of the Notch signal. One candidate for a modifier of Notch function is the Drosophila Suppressor of deltex gene [Su(dx)]. We have isolated four new alleles of Su(dx) and mapped the gene between 22B4 and 22C2. Loss-of-function Su(dx) mutations were found to suppress phenotypes resulting from loss-of-function of Notch signaling and to enhance gain-of-function Notch mutations. Hairless, a mutation in a known negative regulator of the Notch pathway, was also enhanced by Su(dx). Phenotypes were identified for Su(dx) in wing vein development, and a role was demonstrated for the gene between 20 and 30 hr after puparium formation. This corresponds to the period when the Notch protein is involved in refining the vein competent territories. Taken together, our data indicate a role for Su(dx) as a negative regulator of Notch function.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (9)
	Df(1)N-54l9 Df(2L)ast2 Df(2L)dp-79b Df(2L)S2 Df(2L)Su(dx)-7 Df(2L)Su(dx)-52 Df(2L)yan-J2 In(2L)Su(dx)⁵⁶ T(Y;2)Su(dx)⁴
Alleles (14)
	Dl¹⁷¹ dx^ENU dx^S1M E(spl)mβ-HLH^{Scer\UAS.cdCa} H¹ N^Ax-E2 N^unspecified Scer\GAL4^Bx-MS1096 Ser¹ Su(dx)¹ Su(dx)² Su(dx)⁴ Su(dx)⁵⁶ Su(dx)^sp
Constructs (1)
	P{UAS-E(spl)mβ}
Genes (8)
	Dl dx E(spl)mβ-HLH H N Scer\GAL4 Ser Su(dx)
Insertions (1)
	P{GawB}Bx^MS1096