A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Reference Report

Reference
Citation Fostier, M., Evans, D.A., Artavanis-Tsakonas, S., Baron, M. (1998). Genetic characterization of the Drosophila melanogaster suppressor of deltex gene: a regulator of Notch signaling.  Genetics 150(4): 1477--1485. (Export to RIS)
FlyBase ID FBrf0105825
Publication Type Research paper
PubMed ID 9832525
PubMed Abstract The Notch receptor signaling pathway regulates cell differentiation during the development of multicellular organisms. A number of genes are known to be components of the pathway or regulators of the Notch signal. One candidate for a modifier of Notch function is the Drosophila Suppressor of deltex gene [Su(dx)]. We have isolated four new alleles of Su(dx) and mapped the gene between 22B4 and 22C2. Loss-of-function Su(dx) mutations were found to suppress phenotypes resulting from loss-of-function of Notch signaling and to enhance gain-of-function Notch mutations. Hairless, a mutation in a known negative regulator of the Notch pathway, was also enhanced by Su(dx). Phenotypes were identified for Su(dx) in wing vein development, and a role was demonstrated for the gene between 20 and 30 hr after puparium formation. This corresponds to the period when the Notch protein is involved in refining the vein competent territories. Taken together, our data indicate a role for Su(dx) as a negative regulator of Notch function.
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Language of Publication English
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Publication Type Journal
Abbreviation Genetics
Title Genetics
Publication Year 1916-
ISBN/ISSN 0016-6731
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