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Reference
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| Citation |
Fostier, M., Evans, D.A., Artavanis-Tsakonas, S., Baron, M. (1998). Genetic characterization of the Drosophila melanogaster suppressor of deltex gene: a regulator of Notch signaling. Genetics 150(4): 1477--1485. |
| FlyBase ID |
FBrf0105825 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
9832525 |
| PubMed Abstract |
The Notch receptor signaling pathway regulates cell differentiation during the development of multicellular organisms. A number
of genes are known to be components of the pathway or regulators of the Notch signal. One candidate for a modifier of Notch
function is the Drosophila Suppressor of deltex gene [Su(dx)]. We have isolated four new alleles of Su(dx) and mapped the
gene between 22B4 and 22C2. Loss-of-function Su(dx) mutations were found to suppress phenotypes resulting from loss-of-function
of Notch signaling and to enhance gain-of-function Notch mutations. Hairless, a mutation in a known negative regulator of
the Notch pathway, was also enhanced by Su(dx). Phenotypes were identified for Su(dx) in wing vein development, and a role
was demonstrated for the gene between 20 and 30 hr after puparium formation. This corresponds to the period when the Notch
protein is involved in refining the vein competent territories. Taken together, our data indicate a role for Su(dx) as a negative
regulator of Notch function.
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| Biosis |
1999.28356 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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| Associated files |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Genetics |
| Title |
Genetics |
| Authors |
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| Volume range |
1- |
| Year range |
1916- |
| Page range |
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| Publisher |
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| Place of publication |
Austin, TX, etc |
| Language of publication |
English |
| ISBN/ISSN |
0016-6731 |
| CODEN |
GENTAE |
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Data from Reference
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| Aberrations (9)
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| Alleles (14)
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| Constructs (1)
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| Genes (8)
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| Insertions (1)
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