Reference Report

Reference
Citation	Horsfield, J., Penton, A., Secombe, J., Hoffman, F.M., Richardson, H. (1998). decapentaplegic is required for arrest in G1 phase during Drosophila eye development. Development 125(24): 5069--5078.
FlyBase ID	FBrf0105843
Type of publication	Research paper
Offprint Available	Yes
External Crossreferences
PubMed ID	9811590
PubMed Abstract	During eye development in Drosophila, cell cycle progression is coordinated with differentiation. Prior to differentiation, cells arrest in G1 phase anterior to and within the morphogenetic furrow. We show that Decapentaplegic (Dpp), a TGF-β family member, is required to establish this G1 arrest, since Dpp-unresponsive cells located in the anterior half of the morphogenetic furrow show ectopic S phases and ectopic expression of the cell cycle regulators Cyclins A, E and B. Conversely, ubiquitous over-expression of Dpp in the eye imaginal disc transiently inhibits S phase without affecting Cyclin E or Cyclin A abundance. This Dpp-mediated inhibition of S phase occurs independently of the Cyclin A inhibitor Roughex and of the expression of Dacapo, a Cyclin E-Cdk2 inhibitor. Furthermore, Dpp-signaling genes interact genetically with a hypomorphic cyclin E allele. Taken together our results suggest that Dpp acts to induce G1 arrest in the anterior part of the morphogenetic furrow by a novel inhibitory mechanism. In addition, our results provide evidence for a Dpp-independent mechanism that acts in the posterior part of the morphogenetic furrow to maintain G1 arrest.
Biosis	1999.99746
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Language of publication	English
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Abbreviation	Development
Title	Development
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Volume range	99-
Year range	1987-
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Place of publication	Cambridge
Language of publication	English
ISBN/ISSN	0950-1991
CODEN	DEVPED
Data from Reference
Alleles (32)
	CycE^JP Dad^271-68 Dad^P1883 Dad^Δ1883-3a Ecol\lacZ^Dad-P1883 Mad^P1 Med³ Scer\GAL4^hs.PB dpp¹⁰² dpp⁹⁷ dpp⁹⁸ dpp⁹⁹ dpp^Scer\UAS.cSa dpp^d-blk dpp^d-ho dpp^d12 dpp^d14 dpp^d5 dpp^d6 dpp^e87 dpp^e90 dpp^hr4 dpp^hr56 put¹³⁵ put⁶² rux⁸ sax⁴ sax^P shn⁰⁴⁷³⁸ shn¹ tkv⁵ tkv⁷
Constructs (1)
	P{UAS-dpp.S}
Genes (16)
	CycA CycB CycE Dad Ecol\lacZ Mad Med Scer\GAL4 dap dpp put rux sax shn stg tkv
Insertions (2)
	P{lacW}Dad^j1E4 P{lacZ}Dad^P1883